| 徐述,胡晓梅,许勇钢,杨晓红,王洪志,刘锋,麻柔.青黄散加补肾健脾中药治疗骨髓增生异常综合征的临床观察[J].中国中西医结合杂志,2008,(3):215-217 |
| 青黄散加补肾健脾中药治疗骨髓增生异常综合征的临床观察 |
| Effect of Treatment for Myelodysplastic Syndrome by Qinghuang Powder Combined with Chinese Herbs for Reinforcing Shen and Strenghening |
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| DOI： |
| 中文关键词: 骨髓增生异常综合征 青黄散 补肾健脾中药 中西医综合治疗 临床疗效 |
| 英文关键词:myelodysplastic syndrome Qinghuang Powder Chinese herbs for reinforcing Shen and strenghening Pi comprehensive TCM and Western medical therapy clinical efficacy |
| 基金项目:国家自然科学基金(No．30572450) |
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| 摘要点击次数: 1939 |
| 全文下载次数: 5 |
| 中文摘要: |
| 目的观察青黄散加补肾健脾中药治疗骨髓增生异常综合征(MDS)的临床疗效。方法55例MDS患者给予青黄散、补肾健睥汤药及雄性激素等治疗。结果55例MDS患者中,完全缓解11例(20.0%),总有效41例(74.5%)。根据FAB分型,RA/RAS型34例,完全缓解9例(26.5%),总有效28例(82.4%);RAEB型21例,完全缓解2例(9.5%),总有效13例(61.9%),两型间疗效比较差异无统计学意义。按国际预后积分系统(IPSS)评定标准,中危Ⅰ组36例,有效25例(其中完全缓解10例),无效11例。中危Ⅱ组7例,完全缓解1例,有效4例,无效2例。高危组6例,完全缓解0例,有效3例,无效3例。3组疗效比较差异无统计学意义。有效者41例,治疗后白细胞、血红蛋白和血小板计数均较治疗前升高(P<0.05);染色体异常组16例,有效11例(68.8%);染色体正常组33例,有效24例(72.7%);染色体异常与否间疗效比较,差异无统计学意义。结论化瘀补肾为主综合治疗MDS具有确切的临床疗效,疗效与FAB分型、IPSS积分及染色体异常与否无明显相关性。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of Qinghuang Powder combined with Chinese herbs for reinforcing Shen and strenghening Pi in treating myelodysplastic syndrome(MDS).Methods Fifty-five patients with diagnosis fitting to MDS were treated with Qinghuang Powder and decoction for strengthening Pi and reinforcing Shen,in combination with Stanozololum.Results Eleven patients(20.0%)out of the 55 were completely remit- ted(CR),the total effective rate being 74.5%(41/55 cases).By FAB typing,9(26.5%)in the 34 patients of type RA/RAS were CR,with the total effective rate of 82.4%(28/34 cases),and in the 21 patients of type RAEB,9.5%(2/21 cases)were CR with the total effective rate of 61.9%(13/21 cases),showing insignificant statistical difference between the two types(P>0.05).By international prognostic scoring system(IPSS),the treatment was evaluated as CR in 10 patients,effective in 25 and ineffective in 11 in 36 patients of moderate risk groupⅠ,the responding numbers were 1,4,2 in 7 patients of moderate risk groupⅡand O,3,3 in 6 patients of high risk group,respectively,also showing insignificant difference between groups(P>0.05).Levels of Hb, WBC and platelet significantly increased after treatment(P<0.05).By cytogenetics,the effective rate was 68.8%(11/16 cases)in patients with abnormal chromosome and 72.7%(24/33 cases)in those with normal chromosome,with insignificant difference(P>0.05).Conclusion The comprehensive therapy with TCM treat- ment for reinforcing Shen and dissolving stasis in dominance has a definite clinical effect in treating MDS,it was not significantly associated with FAB typing,IPSS score,and chromosome abnormality of patients. |
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