黄芪扶正饮治疗复发性生殖器疱疹的临床观察

作者	单位
史永俭	山东大学第二医院皮肤科
杜锡贤	山东中医药大学附属医院皮肤科
张春红	山东大学第二医院皮肤科
张春敏	山东大学第二医院皮肤科
孟丽亚	山东大学第二医院皮肤科
魏国	山东大学第二医院皮肤科

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中文摘要:

目的观察黄芪扶正饮治疗复发性生殖器疱疹(recurrent genital herpes,RGH)的临床疗效及其对患者外周血相关细胞因子(IL-4、IL-10、IL-12、IL-18)的影响。方法将84例RGH患者随机分成3组,分别用黄芪扶正饮(治疗组,31例)、阿昔洛韦(对照1组,25例)和阿昔洛韦联合干扰素(对照2组,28例),但3组局部皮损均用聚维酮碘溶液治疗,疗程均为4周,6个月后统计复发情况,并用双抗体夹心ELISA法检测3组患者治疗前后外周血细胞因子水平。结果3组患者均痊愈,但治疗组6个月后复发10例,对照2组复发6例,明显低于对照1组(复发18例,P<0.01),治疗组与对照2组比较差异无统计学意义。与健康人比较,治疗前3组患者IL-4、IL-10含量升高,IL-12、IL-18含量降低(P<0.01);治疗后治疗组和对照2组IL-4、IL-10含量下降,IL-12、IL-18含量上升(P<0.05或P<0.01),且下降或上升幅度优于对照1组(P<0.01)。结论黄芪扶正饮能降低RGH的复发率,无明显的不良反应,并能调节机体免疫功能。

英文摘要:

Objective To observe the clinical efficacy of Huangqi Fuzheng Decoction(HQFZD)in treating recurrent genital herpes(RGH)and its influence on related cytokines in peripheral blood.Methods Eighty-four patients with RGH were randomly assigned to 3 groups,the treated group treated with HQFZD(31 cases),the control group A(25 cases)treated with Aciclovir,and the control group B(28 cases)treated with Aciclovir plus interferon.The course of treatment was 3 weeks for all.The relapse rate was estimated at 6 months after treatment, and levels of IL-4,IL-IO,IL-12 and IL-18 in all patients were detected before and after treatment using double- sandwich ELISA.Results All patients were cured after treatment.The relapse rate in the treated group and the control group B was lower than that in the control group A(P<0.01)but insignificant difference was shown be- tween the former two groups.Before treatment,patients’ serum levels of IL4 and IL-10 were significantly higher while those of IL-12 and IL-18 were lower than the normal range(P<0.01).The abnormal change aforementioned reversed after treatment in the treated group and the control group B(P<0.05 or P<0.01),showing a superior effect to that in the control group A(P<0.01).Conclusion HQFZD can reduce the relapse rate of RGH without obvious adverse reaction,and it could also enhance the immunity of the patients.

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