孙良华,李群,王树庆,孙永红,季万胜,乔颜春.慢性萎缩性胃炎胃黏膜EGF、VEGF、PCNA与中医证型关系的研究[J].中国中西医结合杂志,2008,(3):224-227 |
慢性萎缩性胃炎胃黏膜EGF、VEGF、PCNA与中医证型关系的研究 |
Relationship of TCM Syndrome Type of Gastric Mucosal Epithelial Growth Factor, Vascular Endothelial Growth Factor and Proliferative Cell Nuclear Antigen in Patients with Chronic Atrophic Gastritis |
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DOI: |
中文关键词: 慢性萎缩性胃炎 中医证型 免疫组织化学 表皮生长因子 血管内皮生长因子 增殖细胞核抗原 |
英文关键词:chronic atrophic gastritis TCM syndrome type immunohistochemistry epithelial growth factor vascular endothelial growth factor proliferative cell nuclear antigen |
基金项目:山东省中医管理局科研基金项目(No.2005-237) |
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中文摘要: |
目的研究慢性萎缩性胃炎(CAC)胃黏膜表皮生长因子(EGF)、血管内皮生长因子(VEGF)及增殖细胞核抗原(PCNA)与中医证型的关系,探讨中医证型的实质,为临床治疗提供理论依据。方法经胃镜及病理组织学检查确诊的200例CAG患者,进行中医辨证分型,采用免疫组化法检测不同证型CAG患者EGF、VEGF及PCNA的表达水平。结果脾胃虚弱证72例,肝胃不和证43例,脾虚气滞证32例,胃阴不足证24例,脾胃湿热证14例,胃络瘀阻证5例。其中,PCNA表达水平肝胃不和证与脾胃虚弱证、脾虚气滞证、胃阴不足证之间差异有统计学意义(P<0.05);而EGF、VEGF的表达水平在各型之间差异无统计学意义(P>0.05)。结论CAG以脾胃虚弱证和肝胃不和证居多,PCNA的高表达可能是肝胃不和证的诊断依据。 |
英文摘要: |
Objective To study the relationship of TCM syndrome type of gastric mucosal epithelial growth factor(EGF),vascular endothelial growth factor(VEGF)and proliferative cell nuclear antigen(PCNA)in pa- tients with chronic atrophic gastritis(CAG)for exploring the essence of TCM type and providing a theoretical basis of clinical treatment.Methods TCM syndrome type of 200 patients with diagnosis of CAG confirmed by fibro-gas- troscope and pathological examination were differentially classified,and the expressions of EGF,VEGF and PCNA in different types were determined using immunohistoehemistry.Results Patients were differentiated as Pi-Wei de- ficiency type(TypeⅠ)in 72;Gan-Wei disharmony type(TypeⅡ)in 43;Pi-deficieney with qi stagnation type (TypeⅢ)in 32;Wei-yin deficiency type(TypeⅣ)in 24;Pi-Wei clamp-heat type(TypeⅤ)in 14;and Wei- collateral stasis obstruction type(TypeⅥ)in 5.The difference of PCNA expression level between TypeⅡwith TypeⅠ,ⅢandⅣwas significant(P<0.05).No significant difference in expression levels of EGF and VEGF was found among the 6 types(P>0.05).Conclusion TypeⅠandⅡwere the dominant TCM syndrome types in CAG patients;the high expression of PCNA might be a diagnostic evidence for Gan-Wei disharmony syndrome. |
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