中药抗炎灵联合奥美拉唑钠治疗烧伤患者胃肠道功能衰竭的临床观察

作者	单位
宋知仁	解放军169医院 (湖南衡阳421002)
刘志云	解放军169医院 (湖南衡阳421002)
成路	解放军169医院 (湖南衡阳421002)
冷明芳	解放军169医院 (湖南衡阳421002)

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中文摘要:

目的观察中药抗炎灵煎剂联合奥美拉唑钠治疗烧伤患者胃肠道功能衰竭的疗效。方法烧伤后胃肠道功能衰竭患者随机分为两组,治疗组32例(其中急性应激性胃肠黏膜病变伴出血18例,中毒性肠麻痹14例),对照组20例(分别为11例和9例)治疗组用中药抗炎灵煎剂加奥美拉唑钠,对照组单用奥美拉唑钠,并观察治疗前和治疗12 h后胃黏膜内pH值,48 h内急性应激性胃肠黏膜病变伴出血的止血效果和治疗后72 h内中毒性肠麻痹的治疗效果。结果治疗前两组患者胃黏膜内pH明显低于正常值;治疗后治疗组胃黏膜内pH值上升(P<0.05)并接近正常,而对照组上升不明显。急性应激性胃肠黏膜病变伴出血治疗组显效8例,有效6例,无效4例,总有效率为77.8%,对照组分别为2例、3例、6例及45.5%:两组比较差异有统计学意义(P<0.05)。中毒性肠麻痹治疗组显效9例,有效3例,无效2例,总有效率为85.7%,对照组均无效,两组比较差异有统计学意义(P<0.05)。结论中药抗炎灵联合奥美拉唑钠对烧伤患者胃肠道功能衰竭有明显的治疗作用。

英文摘要:

Objective To observe the curative effects of combined therapy with Kangyanling(KYL,a Chi- nese herbal preparation)and Omeprazole on post-burn digestive dysfunction.Methods Patients with post-burn di- gestive dysfunction were assigned to two groups,the 32 in the treated group,including 18 with acute stress gastroin- testinal mucosal hemorrhagic lesion and 14 with toxic enteroparalysis,were treated by KYL plus Omeprazole,and the 20 patients in the control group,11 with acute stress gastrointestinal mucosal hemorrhagic lesion and 9 with tox- ic enteroparalysis were treated with Omeprazole alone.The pH value in gastric mucosa was determined before and 12 h after treatment,the hemostasis effects in 48 h,and the anti-paralysis effects in 72 h were observed as well. Results The pH value in gastric mucosa of both groups before therapy were all lower than the normal range,it raised after treatment in the treated group(P<0.05),approaching to the normal range,but with no significant change in the control group.The total hemostatic rate and the anti-paralysis rate was 77.8% and 85.7% respec- tively in the treated group,and 45.5% and 0% in the control group,all shown statistical significance between groups(P<0.05).Conclusion Combined therapy with Kangyanling and Omeprazole has obvious curative effects on post-burn gastric dysfunction.

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