通达汤系列方治疗抗精神病药所致药源性闭经泌乳综合征的临床观察

作者	单位
丁瑛	浙汀省杭州市第七人民医院 (杭州310013)
钱惠忠	浙汀省杭州市第七人民医院 (杭州310013)
王义强	浙汀省杭州市第七人民医院 (杭州310013)
沈鉴清	浙汀省杭州市第七人民医院 (杭州310013)
朱长江	浙汀省杭州市第七人民医院 (杭州310013)
刘军云	浙汀省杭州市第七人民医院 (杭州310013)
张丽娜	浙汀省杭州市第七人民医院 (杭州310013)
许子明	浙汀省杭州市第七人民医院 (杭州310013)

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中文摘要:

目的观察自拟通达汤系列方治疗药源性闭经泌乳综合征的临床疗效。方法选用因服抗精神病药物引起药源性闭经和(或)泌乳的女性精神分裂症患者100例,随机分为两组(各50例),两组患者在服用抗精神病药物的同时,治疗组给予通达汤系列方治疗,对照组给予安慰剂治疗。并在治疗前,治疗4、8周时测定催乳素水平进行疗效评定。结果两组总完成率为96%;治疗组49例,痊愈31例(63.3%),显效11例(22.4%),有效4例(8.2%),无效3例(6.1%),总有效率为93.9%。对照组47例,痊愈0例,显效3例(6.4%),有效7例(14.9%),无效37例(78.7%),总有效率为21.3%。催乳素水平:两组治疗前比较差异无统计学意义,治疗后治疗组下降(P<0.01),且治疗组下降幅度优于对照组(P<0.05);对照组治疗前后比较差异无统计学意义。结论通达汤系列方治疗抗精神病药物引起药源性闭经泌乳综合征效果满意。

英文摘要:

Objective To observe the clinical effect of self-formulated Tongdatang serial recipe(TDT)in treating antipsychotic drug-induced galaetorrhea-amenorrhea syndrome(GAS).Methods One hundred female schizophrenic patients with antipsychotic drug-induced GAS were selected and equally assigned to the treatment group and the control group at random.Both received antipsychotic drug-therapy,but combined with TDT and pla- cebo respectively.The efficacy was evaluated by determining prolaetin level before,4 and 8 weeks after treatment. Results The treatment course was completed in 96% of patients.Therapeutic efficacy on the 49 patients of the treatment group was cured in 31(63.3%),markedly effective in 11(22.4%),effective in 4(8.2%)and inef- fective in 3(6.1%),with the total effective rate of 93.9%,while in 47 patients of the control group,the corre- sponding cases(%)was 0,3(6.4%),7(14.9%)and 37(78.7%),respectively,with the total effective rate of 21.3%.Prolactin levels in the two groups were insignificantly different before treatment,it reduced in the treat- ment group after treatment(P<0.01),and the decrement in the treatment group was more significant than that in the control group(P<0.05).Conclusion Satisfactory effect could achieved by using TDT for treatment of antip- sychotic drug-induced GAS.

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