益气活血法对稳定性心绞痛阿司匹林不耐受患者血小板聚集率、黏附率和血栓素B<sub>2</sub>的影响

Effects of Supplementing Qi and Activating Blood Circulation Method on Platelet Aggregation Rate,Adhesion Rate and Thromboxane B₂ Level in Patients with Stable Angina Pectoris and Intolerable to Aspirin

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中文关键词: 稳定性心绞痛益气活血法抗血小板阿司匹林不耐受

英文关键词:stable angina pectoris supplementing qi and activating blood circulation method anti-platelet aspirin intolerance

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作者	单位
高陆	天津医科大学研究生院天津市中西医结合医院天津医科大学第二医院心脏科
李永健	天津市中西医结合医院天津医科大学第二医院心脏科
陈康寅	天津医科大学第二医院心脏科
党群	天津市中西医结合医院天津医科大学第二医院心脏科

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中文摘要:

目的探讨益气活血法对稳定性心绞痛阿司匹林不耐受患者的血小板聚集率、黏附率及血栓素B2(thromboxane B2,TXB2)的影响。方法将76例稳定性心绞痛(气虚血瘀证)且无法耐受长时期阿司匹林治疗的患者,随机分为给药组(40例)和西药常规治疗组(对照组,36例),两组均治疗1个月。给药组在西药常规治疗的基础上给予益气活血法治疗。于治疗前和治疗1个月后测定血小板黏附率(platelet adhe-sion rate,PAdR)、聚集率(platelet aggregation rate,PAgR)、TXB2、血小板计数(platelet,Plt)、血红蛋白(hemo-globin,Hb)和大便潜血,记录随访期间心血管事件和胃肠道症状。结果给药组治疗1个月后PAdR、PAgR和TXB2显著降低,与治疗前比较,差异有统计学意义(均P<0·01)。与对照组治疗后比较,给药组PAdR、PAgR和TXB2也显著降低,差异有统计学意义(均P<0·01)。两组患者的胃肠道症状、大便潜血、血小板和血红蛋白等指标在治疗前后及两组间比较,差异均无统计学意义(均P>0·05)。治疗期间,给药组与对照组心血管事件发生率比较,差异无统计学意义(均P>0·05)。结论益气活血法可有效地抑制稳定性心绞痛患者的血小板功能,且并不增加胃肠道的不良反应。本研究未能观测到益气活血法治疗减少患者心血管病事件发生的作用,需大样本研究进一步验证之。

英文摘要:

ObjectiveTo investigate the effects of supplementing qi and activating blood circulation method (YQHX) on platelet aggregation rate (PAgR), platelet adhesion rate (PAdR) and thromboxane B2 (TXB2) level in patients with stable angina pectoris and intolerable to aspirin. MethodsSeventy-six out-patients with stable angina (qi deficiency and blood stasis syndrom) pectoris intolerable to aspirin were randomized into two groups, 40 in the treated group and 36 in the control group. Both received conventional Western medicinal treatment with YQHX to the treated group additionally, for 1 month. PAgR, PAdR, TXB2 level, platelet count, hemoglobin concentration and fecal occult blood were measured before and 1 month after treatment, and the cardiac events as well as digestive symptoms occurred in the observation period were recorded. ResultsPAgR, PAdR and TXB2 level lowered in the treated group after 1-month treatment showed a significant difference to those of baseline, and also to those in the control group (all P<0.01). But no significant difference was found between pre-treatment and post-treatment, also between the two groups in platelet count, hemoglobin concentration, fecal figure and incidence of adverse cardiac events, as well as digestive symptoms (P>0.05). ConclusionYQHX can effectively inhibit the platelet function in patients with stable angina pectoris without aggravation of digestive symptoms. Cardiac event reducing effect of YQHX was not seen in this study, it is necessary for large sampled study for confirmation.

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