中西医结合治疗慢性荨麻疹的疗效观察及对IL-10和IL-18的影响

Effect of Integrative Chinese and Western Medicine in Treating Chronic Urticaria and Its Impact on Interleukin-10 and Interleukin-8 in Peripheral Blood

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中文关键词: 慢性荨麻疹中西医结合抗荨汤白细胞介素

英文关键词:chronic urticaria integrative Chinese and Western medicine Kangqian Decoction interleukin

基金项目:

作者	单位
金彩云	台州学院医学院
王冬莲	浙江省台州医院检验科
方志德	浙江省台州市医药卫生科技情报站

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中文摘要:

目的探讨中西医结合治疗慢性荨麻疹的临床疗效及对血清白细胞介素(IL)-10、IL-18的影响。方法依就诊顺序分为两组。对照组(30例)口服盐酸左西替利嗪片5mg,每天1次。治疗组(32例)在口服盐酸左西替利嗪片的同时加用自拟抗荨汤(柴胡15g防风9g甘草15g牡丹皮15g丹参15g北芪30g五味子12g等),每天1剂,水煎服,2周为1个疗程。治疗2个疗程后评定疗效。两组治疗前后检测IL-10和IL-18水平。结果临床有效率治疗组93·75%;对照组有效率56·67%,两组比较差异有统计学意义(P<0·01)。血清IL-10(ng/L):治疗组(2·96±1·66)明显低于对照组(4·77±2·99);血清IL-18(ng/L):治疗组(50·17±32·35)明显高于对照组(29·44±17·62)。两组比较,差异均有统计学意义(P<0·01)。结论慢性荨麻疹与机体免疫失衡有关,中西医结合治疗可调节机体免疫失衡,提高疗效,减少不良反应及复发率。

英文摘要:

ObjectiveTo study the clinical effects of integrative Chinese and Western medicine in treating chronic urticaria and its impact on peripheral blood content of interleukin-10 (IL-10) and IL-8. MethodsPatients were assigned to the treatment group and the control group according to their sequence of visiting. They were treated orally with levocetirizine hydrochloride 5 mg once a day, but additional Kangqian Decoction (a self-formulated Chinese herbal preparation consisted of thorowax root 15 g, divaricate saposhnikovia root 9 g, licorice root 15 g, moutan bark 15 g, red sage root 15 g, milkvetch root 30 g, and schisandra fruit 12 g, etc.) was given to the treatment group one dose per day, for 2 weeks as one therapeutic course. The efficacy was evaluated after two courses of medication, and patients’ IL-10 and IL-8 levels in the peripheral blood were determined before and after treatment. ResultsThe total effective rate in the treatment group and control group was 93.75% and 56.66% respectively with significance difference between them (P<0.01). After treatment, the level of serum IL-10 was significantly lower while that of IL-8 was significantly higher in the treatment group (2.96±1.66, 50.17±32.35) than that in the control group (4.77±2.99, 29.44±17.62) respectively (P<0.01). ConclusionChronic urticaria was related to the immune unbalance of body. Integrative medicine could adjust immune function to display a quick, potent anti-inflammatory and anti-anaphylactic actions in treating chronic urticaria with less adverse reaction and low recurrent rate.

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