红花黄色素粉针与贝那普利联合治疗糖尿病肾病39例疗效观察

作者	单位
郭登洲	河北省中医院河北医科大学
王月华	河北省中医院河北医科大学
陈志强	河北医科大学
边东	河北医科大学
齐红朝	河北医科大学

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中文摘要:

目的观察红花黄色素粉针与贝那普利(洛汀新)联合治疗糖尿病肾病(DN)的临床疗效。方法将76例DN患者随机分为治疗组39例和对照组37例,两组均予常规降糖治疗,贝那普利口服每次10mg,每日1次。治疗组另予红花黄色素粉针150mg加入生理盐水250mL静脉滴注,每日1次,15日为1个疗程,停用5日后开始第2个疗程,共2个疗程。观察两组临床症状、尿微量白蛋白排泄率(UAER)、血β2-微球蛋白(β2-MG)、尿β2-微球蛋白(β2-MG)、尿α1-微球蛋白(α1-MG)、D-二聚体(D-D)、血浆纤维蛋白原(FIB)变化。结果治疗组总有效率为84·6%,对照组总有效率为59·4%,两组比较差异有统计学意义(χ2=6·83,P<0·05)。治疗后治疗组与对照组比较,症状积分明显减少,差异有统计学意义(P<0·05)。治疗后两组UAER、血β2-MG、尿β2-MG、尿α1-MG均有所降低,与治疗前比较差异有统计学意义(P<0·05或P<0·01);且治疗组与对照组比较,差异有统计学意义(P<0·05);治疗后治疗组FIB、D-D显著下降,与治疗前及对照组比较,差异均有统计学意义(P<0·01),对照组治疗前后差异无统计学意义(P>0·05)。结论红花黄色素粉针与贝那普利联合应用治疗DN,在减少尿蛋白,改善肾功能,改善高凝状态方面明显优于单用贝那普利,提示两药合用在延缓DN进展方面能够发挥各自的优势,起到协同作用。

英文摘要:

ObjectiveTo observe the clinical effect of combined treatment with safflor yellow powder injection and benazepril in treating patients with diabetic nephropathy (DN). MethodsSeventy-six patients with DN were randomly assigned to the treatment group (39 cases) and the control group (37 cases). Conventional treatment for lowering blood glucose was given to both groups, but to the control group 10 mg benazepril was given orally once a day additionally, while to those in the treatment group the same dosage of benazepril po. and 150 mg/d of safflor yellow powder injection by adding in 250 mL 0.9% normal saline for intravenous dripping. The therapeutic course for them all was 15 days, and all patients received two courses with an interval of 5 days. Changes of clinical symptoms, urinary albumin excretion rate (UAER), blood and urinary levels of β2-microglobulin (β2-MG), urinary level of α1-microglobulin (α1-MG), D-dimer (D-D) and plasma fibrinogen (FIB) were observed. ResultsThe total effective rate in the treatment group was higher than that in the control group (84.62% vs 59.45%, P<0.05). The total score of syndrome in the treatment group was lower than that in the control group (P< 0.05). Levels of UAER, β2-MG in serum and in urine, α1-MG in urine were decreased significantly after after 2 courses of treatment in both groups, showing significant difference as compared with before treatment (P<0.05 or P<0.01), and the decrements were more significant in the treatment group than those in the control group (P<0.05); while decrease of FIB, D-D only happened in the treatment group (P<0.01),so the post-treatment data in the treatment group were significantly lower as compared with those in the control group (P<0.01). ConclusionCombined therapy with safflor yellow injection and benazepril is superior to benazepril alone in reducing urinary albumin, improving renal function and blood hyperviscosity manner for patients with DN, suggesting the combination of the two could play their respective superiorities and act in cooperation for retarding the progression of DN.

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