心可舒片对冠心病患者心率变异性的影响

作者	单位
张前	北京大学人民医院心脏中心北京100044
周江云	北京大学人民医院心脏中心北京100044
孙宁玲	北京大学人民医院心脏中心北京100044

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中文摘要:

目的观察中药心可舒片对冠心病患者心率变异性(HRV)的影响。方法选取60例经冠状动脉造影确诊冠心病患者,随机分为治疗组和对照组,每组30例,在冠心病常规治疗基础上,治疗组患者给予心可舒片治疗,对照组给予美托洛尔治疗,疗程均为8周,分别观察患者治疗前后症状及24h动态心电图(Holter)HRV的变化。结果治疗组治疗前后心绞痛发作次数分别为(8.8±3.2)次/周和(4.4±2.1)次/周,对照组分别为(8.4±3.1)次/周和(3.9±2.0)次/周,治疗后两组心绞痛周平均发作次数均明显减少(P<0.05)。HRV分析显示,治疗组治疗前后平均心率分别为(85.44±2.89)次/min和(77.32±2.17)次/min,对照组分别为(83.80±4.30)次/min和(76.70±2.93)次/min,治疗后两组平均心率均明显下降(P<0.05),下降幅度两组间比较差异无统计学意义(P>0.05)。两组治疗后HRV时域指标均明显上升,组间比较差异无统计学意义(P>0.05)。两组低频(LF)、高频(HF)及总功率(TP)频域指标均明显升高,LF/HF及极低频(VLF)均明显降低,治疗组降低更显著(P<0.05)。结论心可舒可改善冠心病患者的HRV,减少其心绞痛发作。

英文摘要:

ObjectiveTo evaluate the effect of Xinkeshu Tablet(XKS) on heart rate variability(HRV) in patients with coronary heart disease(CHD).MethodsSixty patients with their diagnosis of CHD confirmed by coronary angiography were randomized into two groups equally.Besides the conventional treatment for CHD,XKS and Metoprolol were given respectively to patients in the treated group and the control group for 8 weeks.Symptoms and 24 h dynamic ECG were observed before and after treatment.ResultsEpisode of angina pectoris decreased obviously in both groups after treatment,from 8.8±3.2 times per week(the same hereafter) to 4.4±2.1 in the treated group(P<0.05),and from 8.4±3.1 to 3.9±2.0 in the control group(P<0.05).HRV analysis showed that after treatment the average heart rate lowered from 85.44±2.89 beat/min to 77.32±2.17 beat/min in the treated group and from 83.80±4.30 beat/min to 76.70±2.93 beat/min in the control group(both P<0.05),showing no significant difference in extent of lowering between groups(P>0.05).The time-domain indexes elevated in both groups,showing no statistical difference between groups(P>0.05).As for the frequency-domain indexes,low frequency(LF),high frequcncy(HF) and total power raised,while LF/HF and very low frequency lowered in both groups,but the changes were more significant in the treated group(P<0.05).ConclusionXKS could improve HRV in patients of CHD and reduce the episode of angina pectoris in them.

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