清肺化痰祛瘀法治疗急性放射性肺炎的临床研究

作者	单位
林胜友	浙江省中医院杭州310006
韩秀华	山东省莱阳中心医院
杨起初	浙江大学附属邵逸夫医院
刘振东	浙江省中医院杭州310006
冯正权	浙江省中医院杭州310006

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中文摘要:

目的观察清肺化痰祛瘀法联合激素、抗生素治疗放射性肺炎的临床疗效。方法将81患者随机分为单纯激素抗生素组(对照组)41例,清肺化痰祛瘀法联合激素抗生素组(治疗组)40例,两组均治疗21天。治疗前、后以急性放射损伤分级标准(RTOG)评价肺炎程度,观察中医症状疗效及X线胸片疗效,检测治疗前后血清细胞因子白介素-6(IL-6)、转化生长因子-β(TGF-β)水平。结果治疗后,治疗组放射性肺炎等级评价为0、1、2、3、4级的例数分别为23、10、4、2、1例,而对照组的例数分别是14、9、11、4、3例,治疗组的改善明显优于对照组(P<0.01);治疗组中医症状疗效也明显优于对照组(P<0.05)。治疗组治疗后血清IL-6、TGF-β水平均明显低于治疗前,与对照组治疗后比较差异有统计学意义(P<0.05)。结论清肺化痰祛瘀联合激素、抗生素治疗放射性肺炎疗效确切,能有效降低放射性肺炎患者的血清IL-6、TGF-β水平。

英文摘要:

ObjectiveTo observe the therapeutic effect of Qingfei Huatan Quyu method(QHQ,a Chinese medicinal therapy for clearing Fei-heat and dissolving phlegm-stasis) combined with hormone-antibiotic therapy(HAT) on radiation pneumonia(RP).MethodsEighty-one patients with RP were randomized into two groups,41 patients in the control group and 40 in the treatment group were treated with HAT alone and HAT combined with QHQ respectively for 21 days.The severity of RP was evaluated before and after treatment according to the criteria of the radiation therapy oncology group.The effect on TCM symptoms and chest roentgenogram,as well as on plasma levels of interleukin-6(IL-6) and transform growth factor-beta(TGF-beta) were detected.ResultsAfter treatment,number of patients with RP graded as 0,1,2,3,and 4 in the treatment group was 23,10,4,2,and 1,respectively,while in the control group,14,9,11,4,and 3,respectively.The combined therapy showed effects in improving RP grading(P<0.01) and TCM syndromes were superior to those of HAT respectively(P<0.05).Besides,levels of IL-6 and TGF-β were lowered after treatment in the treatment group,showing a significant difference to those in the control group(P<0.05).ConclusionQHQ combined with HAT has a definite therapeutic effect on RP.It could efficiently decrease the plasma levels of IL-6 and TGF-β in patients with RP.

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