当归芍药散抗衰老作用的松果体机制

目的探讨当归芍药散是否通过改善松果体的功能而发挥抗衰老作用。方法老年SD大鼠40只,分别分为假手术组、去松果体组、假手术给药组、去松果体给药组,以去松果体术造成衰老模型,灌胃当归芍药散水煎剂3周,然后用Morris水迷宫测试其学习记忆能力,用放射免疫法测血清褪黑激素(MLT)浓度。结果去松果体组平均逃避潜伏期明显高于其余各组(P<0.05);假手术给药组穿环次数、T象限游泳距离百分比明显高于其余各组(P<0.05)。与夜间MLT浓度比较,假手术给药组和去松果体给药组白天MLT浓度显著增高(P<0.05)。与假手术组比较,假手术给药组白天MLT浓度显著增高(P<0.05);与去松果体组比较,去松果体给药组白天MLT浓度显著增高,夜晚MLT浓度显著降低(P<0.05);与去松果体给药组比较,假手术给药组白天MLT浓度增高(P<0.05)。结论当归芍药散可以促进MLT的分泌,改善学习记忆能力。去除松果体后该方药的作用减弱,当归芍药散促进松果体功能是其抗衰老作用的机制之一。

英文摘要:

ObjectiveTo study whether Danggui Shaoyao Powder(DSP) is by way of improving pineal function to realize its anti-aging effects.MethodsForty aged rats were randomly divided into the sham operated group(A),the pinealectomized group(B),the sham medicated group(C),the pinealectomized and medicated group(D).The medication given was gastric perfusion of DSP for 3 weeks.Learning and memory ability of rats was observed using Morris water maze and the serum melatonin(MLT) concentration of the rats was measured by radio-immunoassay.ResultsThe average escape latency in Group B was significantly longer than that in other groups(P<0.05).The times of passing through the platform and the percentage of swimming distance in Group C were significantly higher than those in other groups(P<0.05).The serum MLT was higher at daytime than at night in Group C and D(P<0.05);that at daytime in Group C was higher than Group A(P<0.05) and also higher in Group D than Group B;that at daytime was higher in Group C than Group D;that at night markedly decreased in Group D as compared with Group B(P<0.05).ConclusionDSP could increase the melatonin secretion and improve learning and memory ability.Since its effects reduced after pinealectomy,it could be deduced that improving pineal function should be one of the action mechanisms for anti-aging.

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