补肾二仙汤治疗卵巢早衰的临床观察

目的探讨补肾二仙汤治疗卵巢早衰患者的临床疗效和免疫调节机制。方法60例卵巢早衰患者按照就诊次序以2:1比例分为两组,治疗组40例予补肾二仙汤治疗,对照组20例采用人工周期疗法,疗程6个月。停药3个月后,观察两组疗效及治疗前后血清生殖激素和T淋巴细胞的变化。结果治疗组总有效率为72.5%(29/40例),对照组为45.0%(9/20例),两组比较差异有统计学意义(P<0.05)。治疗后两组促卵泡激素(FSH)、促黄体生成素(LH)下降,雌二醇(E2)升高(P<0.05);治疗后治疗组血清FSH值降低〔(22.57±12.49)IU/L〕,与对照组〔(31.10±14.50)IU/L〕比较差异有统计学意义(P<0.05)。治疗组治疗后CD4升高、CD8降低、CD4/CD8比值升高,与治疗前及对照组治疗后比较差异均有统计学意义(P<0.01)。结论补肾二仙汤有助于改善卵巢早衰,具有较好的临床疗效。

英文摘要:

Objective To observe the therapeutic effect and immune regulatory mechanism of Bushen Er’xian Decoction(BED) on patients with premature ovarian failure(POF).Methods Sixty patients with POF were randomly assigned to two groups in the ratio of 2∶1,the 40 in the treatment group were treated with BED and the 20 in the control group were treated with artificial menstrual cycle therapy.The clinical efficacy was observed and the changes of serum reproductive hormone and T lymphocytes before and after treatment were observed.Results The total effective rate in the treatment group was 72.5%(29/40 cases),which was higher than that in the control group,45.0%(9/20 cases,P<0.05).Serum follicle-stimulating hormone(FSH) and luteinizing hormone(LH) decreased and estradiol(E2) increased in both groups after treatment(P<0.05),but the level of FSH was lower in the treatment group than in the control group(22.57±12.49 IU/L vs 31.10±14.50 IU/L,P<0.05).CD4 and CD4/CD8 increased,CD8 decreased in the treatment group after treatment,showing significant difference as compared with those before treatment and with those in the control group after treatment(P<0.01).Conclusion BED is favourable for improving POF,being a good remedy with better clinical efficacy.

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