川芎素对肝硬化患者门静脉高压血流动力学的影响

作者	单位
黄忠	四川省自贡市第一人民医院消化科
魏尉	四川省自贡市第一人民医院消化科
钟强	四川省自贡市第一人民医院消化科

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中文摘要:

目的观察川芎素对肝硬化患者门静脉高压血流动力学的影响。方法82例肝硬化患者随机分为两组,对照组27例采用常规保肝治疗,治疗组55例在常规保肝基础上加用川芎素治疗,疗程均为2周。治疗前及治疗2周后测量门静脉内径(PV)、脾静脉内径(SPV)、门静脉最大流速(PVX)、脾静脉最大流速(SPVX)、门静脉血流量(QPV)及内皮素-1(ET-1)浓度,观察药物不良反应。结果治疗后治疗组PV、SPV明显降低(P<0.01),PVX及SPVX明显增加(P<0.01),ET-1明显下降(P<0.01),QPV无明显变化。对照组各项指标无明显变化(P>0.05)。治疗组Child分级A、B级患者PV、SPV及ET-1下降明显(P<0.01),QPV无明显变化(P>0.05),治疗组ChildC级各项指标无明显变化(P>0.05)。结论川芎素能有效降低肝硬化门静脉压力,不影响门静脉血流量,对ChildA、B级患者疗效显著。

英文摘要:

Objective To observe the effect of sodium ferulate on the hemodynamics of hepatic cirrhosis patients.Methods Eighty-two hepatic cirrhosis patients were randomly assigned to two groups,the 27 patients in the control group were treated by conventional liver protecting therapy,and the 55 patients in the treated group were treated with sodium ferulate besides the conventional therapy.The therapeutic course for both groups was two weeks.The following indexes were measured before treatment and two weeks after treatment respectively:inner diameter of portal vein(PV),inner diameter of splenic vein(SPV),maximum portal vein flow rate(PVX),maximum splenic vein flow rate(SPVX),portal vein blood flow(QPV) and endothelin-1(ET-1) concentration.The adverse effect was observed meanwhile.Results In the treated group after treatment,levels of PV,SPV and ET-1 decreased(P<0.01),PVX and SPVX increased significantly(P<0.01),but QPV was unchanged;while no significant change of all the indexes was found in the control group(P>0.05).Further analysis showed that in the treated group,PV,SPV and ET-1 decreased significantly in patients of Child grade A and B(P<0.01),but QPV changed insignificantly(P>0.05),and all indexes were unchanged in patients of Child grade C(P>0.05).Conclusion Sodium ferulate can effectively lower the pressure of portal vein in hepatic cirrhosis patients without any influence on the blood flow of portal vein,the effect is more significant on patients of Child grade A and B.

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