| 谭华,孙曼怡,杨健,洪志飞,张姝翌.复方谷氨酰胺肠溶胶囊联合糖皮质激素灌肠治疗溃疡性结肠炎的临床观察[J].中国中西医结合杂志,2008,(7):645-647 |
| 复方谷氨酰胺肠溶胶囊联合糖皮质激素灌肠治疗溃疡性结肠炎的临床观察 |
| Effect of Retention Enema with Combination of Compound Glutamine Entero-soluble Capsule and Glucocorticoids for Treatment of Ulcerative Colitis |
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| DOI： |
| 中文关键词: 复方谷氨酰胺肠溶胶囊 溃疡性结肠炎 保留灌肠 |
| 英文关键词:compound glutamine entero-soluble Capsule ulcerative colitis retention enema |
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| 中文摘要: |
| 目的观察复方谷氨酰胺肠溶胶囊灌肠治疗活动期溃疡性结肠炎(UC)的疗效及安全性。方法活动期UC患者168例,随机分为两组,在口服柳氮磺胺吡啶(或美沙拉嗪)的基础上,治疗组(86例)每天晚上用复方谷氨酰胺肠溶胶囊联合泼尼松龙及甲硝唑注射液保留灌肠,同时口服复方谷氨酰胺肠溶胶囊0.8g,每天3次。对照组(82例)用泼尼松龙及甲硝唑注射液保留灌肠治疗。治疗2个月后评价两组疗效及主要症状变化情况。结果总有效率治疗组为94.2%(81/86例),对照组为82.9%(68/82例),两组比较差异有统计学意义(P<0.05)。两组治疗后便血和腹痛均改善、疾病活动指数(DAI)降低(P<0.01);且治疗后便血减轻、黏液脓血便消失时间及DAI降低幅度治疗组优于对照组(P<0.05或P<0.01)。两组均未见明显的不良反应。结论复方谷氨酰胺肠溶胶囊口服并联合泼尼松龙及甲硝唑注射液保留灌肠治疗活动期UC近期疗效明显优于只用糖皮质激素及甲硝唑注射液灌肠,且无明显不良反应。 |
| 英文摘要: |
| Objective To observe the therapeutic effect and safety of retention enema with compound glutamine entero-soluble Capsule(CGC) on active ulcerative colitis(UC).Methods One hundred and sixty-eight patients with active UC were randomly assigned to the treatment group(86 patients) and the control group(82 patients).Besides the basic treatment of oral taking salicylazosulfapyridine or mesalazine,they were treated by retention enema with predisolone plus metronidazole injection.In addition,the patients in the treatment group were treated by retention enima with GGC and orally took CGC,0.8 g each time,thrice a day.The efficacy of treatment and the changes in the principal symptoms 2 months after treatment were evaluated.Results The total effective rate in the treatment group was 94.2%(81/86 cases),and that in the control group was 82.9%(68/82 cases),the difference between the two groups was significant(P<0.05).The symptoms of hemafecia and abdominal pain were improved,the disease active index(DAI) was lowered after treatment in both groups(P<0.01),but the improvement of hemafecia,time of disappearance of mucous bloody stool and decrease of DAI in the treatment group were superior to those in the control group(P<0.05 or P<0.01).No adverse reaction was found in all patients.Conclusion The retention enema with glucocorticoid plus metronidazole combined with CGC shows an immediate effect obviously superior to that treated with glucocorticoids and metronidazole alone,and with no adverse reaction. |
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