血清表皮生长因子对进展期寻常型银屑病的影响及清热凉血解毒中药对其调控作用

Impact of Serum Epidermal Growth Factor on Progressive Psoriasis Vulgaris and Regulation of Chinese Herbal Medicine for Cleaving Heat,Cooling Blood,and Detoxicating on It

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中文关键词: 表皮生长因子银屑病清热凉血解毒

英文关键词:epidermal growth factor psoriasis Chinese herbal medicine for cleaving heat,cooling blood,and detoxicating

基金项目:浙江省中医管理局科研课题(No.2006C139)

作者	单位
马丽俐	浙江中医药大学附属第一医院
陈培丰	浙江中医药大学附属第一医院
骆丰	浙江中医药大学附属第一医院
余土根	浙江中医药大学附属第一医院

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中文摘要:

目的探讨血清表皮生长因子(epidermal growth factor,EGF)对进展期寻常型银屑病病情的影响和清热凉血解毒中药对其调控作用。方法选择31例进展期寻常型银屑病患者(治疗组)和17名健康人作为对照组,采用ELISA法检测血清EGF水平,皮损面积和严重性指数(psoriasis area and severity index,PA-SI)评定病情严重程度,观察口服清热凉血解毒颗粒10周后患者EGF水平和病情的变化。结果治疗组治疗前EGF值为(175.35±179.86)ng/L,显著高于对照组(72.05±63.01)ng/L,差异有统计学意义(t=-2.888,P=0.006),治疗后下降至(121.67±94.74)ng/L,与治疗前及对照组比较差异均有统计学意义(t=2.155,P=0.04;t=-2.146,P=0.037)。治疗前PASI平均为(9.65±5.82)分,较治疗后(5.74±4.69)分差异有统计学意义(t=7.740,P<0.01)。对EGF与PASI进行直线回归分析,两者无相关性(r=0.030,P=0.872;r=0.050,P=0.793)。结论清热凉血解毒中药可降低患者EGF水平,这可能是这类中药可改善银屑病病情的作用机制之一。

英文摘要:

Objective To investigate the impact of serum epidermal growth factor(EGF)on progressive psoriasis vulgaris and the regulatory effect of Chinese herbal medicine on it.Methods Serum level of EGF was measured in 31 patients with progressive psoriasis vulgaris(the tested group)and 17 healthy subjects(the control group)by ELISA.The changes in EGF level and condition of illness were observed before and after patients orally administered Chinese composite recipe for clearing heat,cooling blood and removing toxic substances for 10 weeks,and the severity of illness was assessed by psoriasis area and severity index(PASI)as well.Results Serum level of EGF in patients was 175.35±179.86 ng/L before treatment,markedly higher than that in healthy subjects(72.05±63.01 ng/L),showing significant difference between them(t=-2.888,P=0.006);it reduced to 121.67±94.74 ng/L after treatment,significantly different to that before treatment(t=2.155,P=0.04),but still higher than that in the control(t=-2.146,P=0.037).Average PASI was 9.65±5.82 before treatment and 5.74±4.69 after treatment,displaying a significant reduction(t=7.740,P<0.01).Linear regression analysis showed no apparent correlation between serum EGF level and PASI(r=0.030,P=0.872;r=0.050,P=0.793).Conclusion Serum level of EGF might be an important factor related to the progress of psoriasis.Chinese herbal medicine for clearing heat,cooling blood and removing toxic substances can lessen the severity of psoriasis,its action in reducing serum EGF is possibly one of the mechanisms for these kinds of herbs in treating psoriasis.

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