芪参活血颗粒联合氟康唑对深部白色念珠菌感染小鼠生存率的影响

作者	单位
李世荣	首都医科大学附属北京友谊医院感染科
王红	首都医科大学附属北京友谊医院感染科
张淑文	首都医科大学附属北京友谊医院感染科
王宝恩	首都医科大学附属北京友谊医院感染科

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中文摘要:

目的观察芪参活血颗粒联合氟康唑对深部白色念珠菌感染小鼠生存率的影响。方法通过尾静脉注射白色念珠菌标准菌株,建立正常免疫力及免疫力低下小鼠深部白色念珠菌感染的动物模型,分别随机分成4组:模型组、中药(芪参活血颗粒)治疗组、西药(氟康唑)治疗组和中西药治疗组,另设空白对照组。模型及空白对照组给予生理盐水,其余组给予相应药物灌胃,连续给药并观察30天。观察各组小鼠的生存时间,计算总体生存率。结果(1)免疫力正常的深部白色念珠菌感染模型组和中药治疗组生存率为0,中西药结合组与西药组生存率分别为79%、78%,后两者比较差异无统计学意义(P>0.05)。(2)免疫力低下的深部白色念珠菌感染模型组和中药治疗组生存率为0,中西药结合组与西药治疗组生存率分别为36%、7%,中西药结合组高于西药治疗组(P<0.05)。结论芪参活血颗粒联合氟康唑应用较单纯应用氟康唑更能提高免疫力低下小鼠深部白色念珠茵感染的生存率。

英文摘要:

Objective To observe the effect of Qishen Huoxue Granule (QHG) combined with Fluconazole on the survival rate of mice with systemic C.albaicans (CA) infection.Methods Deep CA infection model mice, with normal and low immunity,were established separately by injecting standard strain of CA via caudal vein,and were divided into 4 groups at random,treated by gastrogavage with normal saline (Group A),QHG (Group B), Fluconazole (FCZ,Group C) and QHG+FCZ (Group D) respectively,and a blank group was set up with normal mice for control.The survival time and the total survival rate in 30 days in various groups were recor- ded.Results For mice with normal immunity,the survival rate in Group D and C was 79% and 78% respective- ly,showing no difference between them (P>0.05).But for those with low immunity,it was 36% and 7% respec- tively,and the survival rate significantly higher in Group D than in Group C (P<0.05).Conclusion As com- pared with those treated with FCZ alone,QHG combined with FCZ can raise the survival rate of the immuno-sup- pressed mice with systemic CA infection.

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