赤芍801治疗非ST段抬高急性冠状动脉综合征的临床观察

作者	单位
蒋跃绒	中国中医科学院西苑医院心血管病研究室
殷惠军	中国中医科学院西苑医院心血管病研究室
李立志	中国中医科学院西苑医院心血管病研究室
陈可远	中国中医科学院西苑医院心血管病研究室
陈可冀	中国中医科学院西苑医院心血管病研究室

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中文摘要:

目的观察注射用赤芍801联合西医标准药物治疗非ST段抬高急性冠状动脉综合征(不稳定性心绞痛和急性非ST段抬高心肌梗死)患者的疗效及对血清炎症标志物和血小板活化的影响。方法选择符合入选标准的非ST段抬高急性冠脉综合征患者55例,随机分为赤芍801治疗组(27例)和丹参对照组(28例),在西医标准药物治疗的基础上加用相应药物,均连续用药14天。观察两组心绞痛和心电图疗效,并采用流式细胞术检测患者治疗前后血小板膜糖蛋白(GP)Ⅱb-Ⅲa受体、CD62p受体表达阳性率及平均荧光强度(MFI),酶联免疫吸附(ELISA)法检测患者治疗前后血清炎症标志物高敏C反应蛋白(Hs-CRP)水平。结果两组心绞痛有效率和心电图有效率比较差异无统计学意义,两组治疗后血清Hs-CRP水平、GPⅡb-ⅢaMFI、CD62p阳性率较治疗前明显降低(P<0.05),赤芍801组与丹参对照组比较,血清Hs-CRP水平及GPⅡb-ⅢaMFI有进一步降低的趋势,但差异无统计学意义。结论在西医标准药物治疗的基础上,联用赤芍801与联用丹参粉针对非ST段抬高急性冠脉综合征患者心绞痛及心电图疗效相当。

英文摘要:

Objective To investigate the therapeutic effects of propyl gallate (PrG) in combination with standard medication on patients with non-ST-elevation acute coronary syndrome (NST-ACS),including unstable angina and acute non-ST-elevation myocardial infarction,and its influences on serum inflammatory marker and platelet activation.Methods Fifty-five patients with NST-ACS were randomly assigned to two groups.Accessory to the standard Western medicine,the 27 patients in the tested group treated with PrG and the 28 in the control group with salvia composite (SC),all being medicated for 14 days.Effects on angina pectoris and electrocardiogram were observed.The positive rate and mean fluorescence density (MFI) of GPⅡb-Ⅲa and CD62p expression on platelet surface were detected using flow cytometer;the serum concentration of high sensitive C-reactive protein (Hs-CRP) was determined using ELISA before and after treatment respectively.Results The therapeutic effects on angina and electrocardiogram between the two groups showed no significant difference.Serum level of Hs-CRP,GPⅡb-Ⅲa MFI and CD62p positive rate were significantly lowered after treatment in both groups (P<0.05),no significant difference was found between groups,though the lowering of Hs-CRP and GPⅡb-Ⅲa MFI in the tested group dis- played a further decreasing trend.Conclusion In combination with standard medication of Western medicine,PrG and SC showed no obvious difference in the therapeutic effect and influences on angina pectoris and electrocardio- gram in patients with non-ST-elevation acute coronary syndrome.

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