“病证方剂分析——吸收/代谢方剂原成分配伍”研究思路

Analysis of Prescription for Special Disease/Syndrome——Compatibility of Absorbed/Metabolized Components from Original Formula——A Thinking of Research

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DOI：

中文关键词: 方剂配伍成分配伍

英文关键词:prescription dispensation combining of various components

基金项目:中国博士后科学基金项目(No．20060401027)

作者	单位
张红敏	广州中医药大学第二临床医学院,广东省中医院/广东省中医药科学院

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中文摘要:

方剂药效物质基础是中医药学科发展急待解决的关键问题。本文提出"病证方剂分析——吸收/代谢方剂原成分配伍"研究新思路。首先进行"病证方剂分析",从特定病证机体的药物血清中分析方剂来源成分及代谢产物。再进行"吸收/代谢方剂原成分配伍"研究,应用均匀设计,找出各成分对方剂疗效的贡献度,剔除无关及作用方向相反成分,找出药效最大时最佳成分配伍方剂。该思路在确保新方剂有效性前提下,既能保留配伍的优势与特色,又能明确药效物质;既能得到药效成分清楚的新方剂,又能定量阐释各成分间配伍关系。

英文摘要:

What is the pharmacodynamic active components in Chinese medical prescription is a key problem in urgent need to solve for the development of traditional Chinese medicine (TCM).A new thinking of TCM re- search,"analysis of prescription for special disease/syndrome-compatibility of absorbed/metabolized components from original prescription",was proposed firstly,to analyze and seek out the components or metabolites originated from the administered prescription in blood serum of the organisms with special disease and syndrome.Secondly,to study the compatibility of these absorbed/metabolized components.Then,using a homogeneous design to find out the contribution of each component to the effectiveness of the prescription,eliminate the irrespective or contra-ori- entation effected components,so as to form the best combination of various components for the prescription with the optimal therapeutic efficacy.By this way,the validity of the prescription with new formed combination could be en- sured,not only the predominance and characteristic of combined utilization of traditional Chinese drugs be retained, but also the pharmaeodynamic components of the refined prescription be identified,a new prescription with clear pharmacodynamic constitution be obtained and the dispensing relation among various components be explained clearly and quantitatively.

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