| 盛正和,刘毅斌,黄艳霞,陈柳芳,刘溯章,赵志雄,陈大宇.祛风除湿活血养阴中药治疗类风湿关节炎活动期临床观察[J].中国中西医结合杂志,2008,(11):990-993 |
| 祛风除湿活血养阴中药治疗类风湿关节炎活动期临床观察 |
| Clinical Observation on Treatment of Active Rheumatoid Arthritis with Chinese Herbal Medicine |
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| DOI： |
| 中文关键词: 关节炎 类风湿 祛风除湿 活血养阴 中药 |
| 英文关键词:arthritis rheumatoid expell evil-wind and remove dampness promote blood circulation and invigorating yin Chinese herbal medicine |
| 基金项目:广西壮族自治区卫生厅基金资助项目(No.Z2006248) |
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| 中文摘要: |
| 目的研究祛风除湿活血养阴中药对类风湿关节炎活动期的影响。方法67例活动期类风湿关节炎病例按病情、年龄、性别均衡后分为基础治疗组(22例)、激素组(23例)及中药组(22例),分别采用非类固醇抗炎药+免疫抑制剂、小剂量泼尼松+非类固醇抗炎药+免疫抑制剂、中药+非类固醇抗炎药+免疫抑制剂治疗8周,评价疗效和不良反应积分。结果基础治疗组总有效率20.0%(4/20),激素组81.0%(17/21),中药组85.7%(18/21),激素组和中药组优于基础治疗组(P<0.01)。治疗前疾病活动分数(DAS)3组组间比较差异无统计学意义。治疗后中药组和激素组Ritchie关节指数(RAI)、肿胀关节数目(SwJ+s)、红细胞沉降率(ESR)、通过100mm视力对照表进行的一般健康状态(GH)评估、DAS均有明显改善(P<0.05);基础治疗组仅GH有明显改善(P<0.05)。DAS治疗前后差值3组组间比较:中药组(0.92±0.59)和激素组(0.87±0.60)比较,Z=0.422,P=0.673;中药组和基础治疗组(0.25±0.77)比较,Z=3.836,P=0.000;激素组和基础治疗组比较Z=3.795,P=0.000。不良反应的累计积分3组排序为中药组(3.76±2.72)<基础治疗组(9.10±6.01)<激素组(14.38±9.36),3组组间比较差异有统计学意义(P<0.05)。结论中西医结合治疗类风湿关节炎活动期具有较好疗效,且不良反应较少。 |
| 英文摘要: |
| Objective To study the efficacy and safety of Chinese drugs for expelling evil-wind,removing dampness,promoting blood circulation and invigorating yin in treating active rheumatoid arthritis(RA).Methods Sixty-seven patients with active RA were randomized into 3 groups,the Group A,B and C.They were made coequal in terms of age,sex and condition of disease and treated respectively with basic treatment(non-steroid anti-inflammation drug combined with immune inhibitor)only,basic treatment + small dose prednisone,and basic treatment + Chinese herbal medicine,all for 8 weeks.The efficacy and adverse effects of treatment were analyzed by scoring.Results The total effective rate was 20.0%(4/20)in Group A,81.0%(17/21)in Group B and 85.7%(18/21)in Group C,the latter two were superior to the former one(P<0.01).Before treatment,comparison of disease activity score(DAS)among the three groups showed no significant difference(P>0.05).After treatment,improvements of Ritchie arthritis index(RAI),number of swollen joint,erythrocyte sedimentation rate(ESR),general health(GH),and DAS were shown in Group B and C(P<0.05),while in Group A,improvement was only shown in GH(P<0.05).The difference of DAS between pre-and post-treatment was 0.25±0.77 in Group A,0.87±0.60 in Group B and 0.92±0.59 in Group C,showing statistical significance between Group A vs B and A vs C(P=0.0000).The total accumulative score of adverse reaction was 3.76±2.72 in Group C,9.10±6.01 in Group A and 14.38±9.36 in Group B,also showing statistical significance among groups(P<0.05).Conclusion The combination of Chinese and Westerw medicine for active RA is effective and safe. |
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