补肾通督方对强直性脊柱炎血清TNF-α及TGF-β<sub>1</sub>水平的影响

作者	单位
许敬人	上海市东方医院
张春燕	上海市东方医院
李伟民	上海市东方医院
林研	上海市东方医院
茅惠明	上海市东方医院
郭琛军	上海市东方医院
陈翠玲	上海市东方医院

摘要点击次数: 1679

全文下载次数: 2

中文摘要:

目的探讨肿瘤坏死因子α（tumor necrosis factor-α,TNF-α）、转化生长因子β₁（transforming growth factorβ₁,TGF-β₁）与强直性脊柱炎（ankylosing spondylitis,AS）发病的关系及补肾通督方对AS患者血清TNF-α、TGF-β₁的影响。方法采用酶联免疫法（ELISA）对治疗Ⅰ组（30例,采用柳氮磺吡啶治疗）和治疗Ⅱ组（35例,采用补肾通督方治疗）患者治疗前及治疗24周后的TNF-α、TGF-β₁水平进行测定,并设立30名健康体检人员作为正常组。同时测定两组AS患者治疗前后的血沉（ESR）、C-反应蛋白（CRP）。结果治疗前两组患者血清TNF-α水平增高,血清TGF-β₁水平降低,与正常组比较差异有统计学意义（P<0.01）,血清TNF-α水平与ESR、CRP呈正相关（r=0.296,r=0.249;P<0.05）。血清TGF-β₁水平与ESR、CRP无统计学意义相关性（r=-0.222,r=-0.203;P>0.05）。Ⅱ组治疗后,AS患者血清TNF-α水平明显降低,血清TGF-β₁水平提高,且ESR、CRP显著降低（P<0.01）。结论补肾通督方可调整AS患者血清TNF-α、TGF-β₁水平,从而抑制免疫炎症反应,达到治疗AS的作用。

英文摘要:

Objective To investigate the relationship of tumor necrosis factor-or （TNF-α） and transforming growth factorβ₁（TGF-β₁） with the occurrence of ankylosing spondylitis （AS）,and the effects of Bushen Tongdu Decoction （BTD） on serum TNF-αand TGF-β₁ levels in patients.Methods Seventy five AS patients were as- signed to two groups,30 in the group I treated with Azulfidine and 35 in the groupⅡtreated with BTD.ELISA was adopted to detect the levels of TNF-αand TGF-β₁ in patients before and after 24-week treatment.Meantime, erythrocyte sedimentation rate （ESR） and C-reactive protein （CRP） were measured as well.Besides,the levels of TNF-αand TGF-β₁ in 30 healthy persons were also detected for normal control. Results Before treatment,as compared with normal control,the TNF-αincreased and TGF-β₁ decreased （P<0.01） in the two treatment groups;the serum level of TNF-αwas positively correlated with ESR and CRP （r=0.296,r=0.249;P<0.05） , but the serum level of TGF-β₁ showed no correlation with them （r=-0.222,r=-0.203;P>0.05）.After treatment,TGF-β₁ increased,while TNF-ct,CRP and ESR decreased in groupⅡ（P<0.01）.Conclusion BTD can regulate TNF-αand TGF-β₁ levels to suppress the immune inflammatory reaction so as to treat AS.

关闭