疏风凉血汤辅助治疗激素依赖性皮炎临床观察

作者	单位
白永晟	山东省青岛市海慈医疗集团皮肤科
周春英	山东省青岛市海慈医疗集团皮肤科
王建青	山东省青岛市黄岛区中医院皮肤科

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中文摘要:

目的观察中药疏风凉血汤治疗激素依赖性皮炎的临床疗效。方法将116例激素依赖性皮炎患者随机分成两组。对照组单纯予西药对症治疗(口服氯雷他定10 mg,50%葡萄糖20 mL加10%葡萄糖酸钙10 mL、维生素C 3.0 g,静脉推注,每日1次);治疗组在此基础上加用疏风凉血汤(白茅根30 g生地30 g牡丹皮15 g荆芥穗15 g防风10 g黄芩15 g连翘15 g栀子10 g赤芍10 g僵蚕10 g地肤子15 g茯苓15 g生甘草10 g)水煎服,每日1剂,4周为1个疗程。以潮红(红斑)、肿胀、毛细血管扩张、炎症性丘疹、瘙痒及其他不适感(疼痛、灼热、干皱等)为观察指标,分别按其严重程度的不同分4个等级计分,并根据治疗前后病情的积分减少率评定疗效并观察治疗过程中出现的不良反应和复发情况。结果治疗组愈显率为76.32%,有效率为94.74%;对照组愈显率为42.50%,有效率为77.50%。两组愈显率和有效率比较,差异均有统计学意义(P<0.01,P<0.05)。治疗组有5例服药后出现轻度腹泻,有3例服药后出现轻度恶心和上腹部不适感,对照组中有2例服药后出现轻度嗜睡,均未影响正常治疗。随访3个月,治疗组复发率为16.00%,明显低于对照组的42.50%(P<0.01)。结论疏风凉血汤治疗激素依赖性皮炎较单纯西药治疗疗效好,复发率低。

英文摘要:

Objective To study the clinical efficacy of Shufeng Liangxue Decoction (SLD) in treating hor- mone dependence dermatitis (HDD).Methods One hundred and sixteen patients with HDD were randomly as- signed to two groups.Both were treated with symptomatic Western medical therapy,including oral taken of lorata- dine 10 mg,and intravenous injection of 10% calglucon 10 mL and vitamin C 3.0 g adding in 20 mL 50% glu- cose,once per day,and to the test group,one dose of SLD consisting of imperata rhizome 30 g,rehmannia root 30 g,moutain bark 15 g,schizonepeta spike 15 g,divaricate saposhnikovia root 10 g,scutellaria root 15 g,forsythia fruit 15 g,cape-jasmine fruit 10 g,red peony root l0 g,white-stiff silkworm l0 g,broom cypress fruit 15g,Indian bread 15 g and licorice root 10 g,was given every day by decocting with water.The course of treatment was 4 weeks.Symptoms of patients,including redden-swollen skin,capillary dilatation,inflammatory papula,itching and other discomfort sensation (pain,burning,dry,buckled) were scored before and after treatment according to their severity.The efficacy was evaluated by the change in scores of symptoms,the adverse reactions occurring in the therapeutic course and the relapse rate after treatment were observed as well.Results The cure-obvious effec- tive rate was 76.32% in the test group and 42.50% in the control group;the total effective rate in them was 94.74% and 77.50% respectively,all showing significant difference (P<0.05) between groups.In the test group,slight diarrhea appeared in 5 patients and slight nausea with upper abdominal discomfort in 3;while in the control group,slight somnolence appeared in 2,but all these adverse reactions did not affect the treatment.A 3- month follow-up study showed that the relapse rate in the test group was significantly lower than that in the control group (16.00% vs 42.50%,P<0.01).Conclusion SLD is effective and safe in treating HDD,with the effica- cy better and relapse rate lower than those of treatment with Western medicine alone.

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