消瘤保肺丸配合化疗对中晚期非小细胞肺癌患者生活质量的影响

目的评价消瘤保肺丸配合化疗对Ⅲ-Ⅳ期非小细胞肺癌(NSCLC)患者生活质量的影响。方法选取符合入选标准的病例40例,随机分成两组:消瘤保肺丸加化疗组(治疗组,20例)和单纯化疗组(对照组,20例)。观察两组治疗前后肺癌患者生活质量测定量表(Functional Assessment of Cancer Therapy,FACT-L)的变化。结果治疗组身体状况的计分相对稳定,对照组随时间延长下降明显,与治疗前及治疗组同期比较,差异均有统计学意义(P<0.05)。治疗组情绪状况、功能状况和附加关注状况的计分从第3次采集开始逐步上升;对照组功能状况、附加关注状况2项在治疗早期有改善,随着治疗时间的延长,患者各项生活质量反而下降,两组比较,差异有统计学意义(P<0.05)。两组中晚期肺癌患者的医患关系及社会/家庭状况均无明显变化。结论消瘤保肺丸配合化疗可明显改善中晚期NSCLC患者生活质量。

英文摘要:

Objective To objectively assess the influence of Xiaoliu Baofei Pill (XBP) combined with chemotherapy on quality of life (QOL) of patients with stage Ⅲ-Ⅳ non-small cell lung cancer (NSCLC). Methods Forty NSCLC patients were equally randomized into 2 groups,the treated group treated with XBP plus chemotherapy,and the control group treated with chemotherapy alone. Patients′ QOL was assessed by Functional Assessment of Cancer Therapy (FACT-L) before and after treatment. Results The scores of the physical condition in the treated group was relatively stable while it lowered significantly as time went by in the control group,significant difference was shown as compared with before treatment and with that in the treated group at the same time points (P<0.05); scores of the mood condition,the function conditions and additional concerned condition were improved gradually from the 3rd collection in the treated group,but decreased in the control group,although some improvement of mood and function conditions had revealed temporarily in the early stage of treatment. Comparison between groups showed significant difference (P<0.05). Besides,no significant change was found in domains of patient-doctor relation and society/family condition in both groups. Conclusion XBP combined with chemotherapy can obviously improve the QOL of advanced NSCLC patients.

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