癌基因和抑癌基因中的阴阳

癌症发生是癌基因(阳)和抑癌基因(阴)逐渐不平衡表达的结果,二者在调控细胞生长和增殖过程中发挥相反作用。以癌基因myc和抑癌基因p53为例,说明在癌基因和抑癌基因中同样存在阴阳。阴基因p53的阴中之阴是抑制细胞生长促进细胞凋亡;阴中之阳是修复受损DNA,使细胞继续存活。阳基因myc的阳中之阳是促进细胞生长和增殖;阳中之阴是诱导细胞凋亡。阐明癌基因和抑癌基因中的阴阳作用,对于癌症全面深入研究具有重要意义。

英文摘要:

Objective Oncogene and antioncogene play contrary effects on the cell growth and proliferation controlling process,and cancer occurs when the presence of imbalance expression between them. That means there is yin-yang relationship between oncogene (yang) and antioncogene (yin),and also inside both of them. Taking the oncogene myc and antioncogene p53 for example,the yin gene p53 acts,in the yin side,to promote cell apoptosis and inhibit cell growth,while in the yang side,it facilitates for repairing the injured DNA to keep cell survival; the yang gene myc,promoting cell growth and proliferation in the yang side and inducing cell apoptosis in the yin side. To elucidate the yin-yang reactions between oncogene and antioncogene would be of important significance in the all-round and profound research of cancer.

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