景天通脉方对实验性兔动脉粥样硬化的影响

作者	单位
赵翠霞	新疆医科大学
热娜·卡斯木	新疆医科大学药学院天药生药教研室
王晓梅	新疆医科大学药学院天药生药教研室
王新玲	新疆医科大学药学院天药生药教研室
施建明	广东医学院

摘要点击次数: 1454

全文下载次数: 2

中文摘要:

目的评价不同剂量景天通脉方对动脉粥样硬化斑块的抑制作用。方法健康新西兰兔54只随机分为:正常对照组,高胆固醇组(模型组),血脂康组,景天通脉方小、中、大剂量组,共6组;除正常对照组外,其余大鼠采用高胆固醇饲料并免疫损伤诱发的动脉粥样硬化斑块模型,观察各组血脂和C-反应蛋白(CRP)以及主动脉斑块/内膜面积比、内/中膜厚度比等并比较。结果对血脂的影响:模型组与正常对照组比较,血清总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白胆固醇(LDL-C)均升高,差异均有统计学意义(P<0.05);血脂康组及景天通脉方小、中、大剂量组TC、LDL-C均明显低于模型组(P<0.05),景天通脉方中剂量组明显低于小、大剂量组及血脂康组(P<0.05);TG景天通脉方小、中、大剂量组及血脂康组与模型组比较差异无统计学意义(P>0.05);而高密度脂蛋白胆固醇(HDL-C)景天通脉方大剂量组、血脂康组高于景天通脉方小、中剂量组,正常对照组和模型组(P<0.05)。对CRP的影响:模型组明显高于正常对照组(P<0.05),景天通脉方3组、正常对照组、血脂康组间比较差异均无统计学意义(P>0.05)。正常对照组无斑块和内、中膜增厚,景天通脉方组与模型组比较,斑块面积、内膜厚度、中膜厚度、斑块/内膜面积比、内/中膜厚度比均明显下降(P<0.05),景天通脉方中剂量组明显低于小、大剂量组及血脂康组(P<0.05)。结论景天通脉方具有抑制动脉粥样硬化的作用,可能是通过调脂、抗炎作用来完成,效应以中剂量(人的等效剂量)为佳。

英文摘要:

Objective To evaluate the inhibiting effects of Jingtian Tongmai Recipe(JTTMR) in different dosages on atherosclerotic plaque using the arteriosclerosis rabbit model induced by high cholesterol diet supplemented with immunological injury.MethodsFifty-four healthy New Zealand rabbits were randomly divided into six groups: the normal control group,the model group,the Xuezhikang(XZK) treated group and the three JTTMR treated groups treated respectively with low(1.29 g/kg/day),medium(2.57 g/kg/day) and high(5.14 g/kg/day) dosage of JTTMR.Indexes including serum lipids,C-reactive protein(CRP),and area ratio of aortic plaque/intima(PIR),and intima-media thickness ratio(IMT) were examined.ResultsComparison of blood lipids showed that serum levels of total cholesterol(TC),triglyceride(TG) and low-density lipoprotein cholesterol(LDL-C) were higher significantly in the model group than in the normal group(P<0.05);TC and LDL-C were lower in the XZK group and the JTTMR groups than in the model group(P<0.05);and these indexes were significantly lower in the medium dose JTTMR group than those in the low and high dose JTTMR groups(P<0.05);while no significant difference of TG between the model group,the JTTMR groups and the XZK group were observed(P>0.05).As for level of high-density lipoprotein cholesterol(HDL-C),that in the XZK group and high dose JTTMR group was higher than that in the other 4 groups(P<0.05).Comparison of CRP showed that it was higher in the model group than in the normal group(P<0.05),while the difference among the other 4 groups was insignificant(P>0.05).No plaque and increase of intima/media thickness was found in the normal group;either PIR or IMT were lesser in the JTTMR groups than those in the model group(P<0.05),and comparison among the three JTTMR groups showed those in the medium dose group was the least(P<0.05).ConclusionJTTMR has arteriosclerosis inhibiting effect,which might be realized through its anti-inflammatory and lipids regulating actions,but the effects are not dose-dependent.The optimal effect is showed by using medium dose of JTTMR,equivalent to the dose used for human adult.

关闭