| 李艳,徐碧云,肖芳,欧碧阳,杨志敏.加味逍遥散对心理应激性失眠患者睡眠的影响[J].中国中西医结合杂志,2009,(3):208-211 |
| 加味逍遥散对心理应激性失眠患者睡眠的影响 |
| Effect of Modified Xiaoyao Powder for Improving Sleep in Patients with Psychological Stress Insomnia |
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| DOI： |
| 中文关键词: 加味逍遥散 心理应激 失眠 匹茨堡睡眠指数量表 多导睡眠监测 |
| 英文关键词:Jiawei Xiaoyao Powder psychological stress insomnia Pittsburgh sleep quality index polysomnography |
| 基金项目:国家自然科学基金资助课题(No.30400611) |
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| 摘要点击次数: 1407 |
| 全文下载次数: 9 |
| 中文摘要: |
| 目的探讨加味逍遥散对心理应激性失眠患者主客观睡眠的影响。方法将入选的33例患者随机分为中药组(9例)、西药组(5例)、中西医结合组(结合组,9例)和对照组(10例)。分别给予加味逍遥散加舒乐安定安慰剂、舒乐安定加加味逍遥散安慰剂、加味逍遥散加舒乐安定、加味逍遥散安慰剂加舒乐安定安慰剂临床干预。所有入组患者治疗前及治疗6周后均行匹茨堡睡眠指数量表(PSQI)、睡眠状况自评量表(SRSS)和多导睡眠监测(PSG)评定。结果(1)主观睡眠质量:与治疗前比较,治疗后中药组、结合组和对照组PSQI及SRSS评分明显下降(P<0.05),西药组PSQI及SRSS评分治疗后有所下降,但差异无统计学意义(P>0.05)。(2)客观睡眠质量:4组患者治疗前后总睡眠时间、Ⅰ期睡眠、Ⅱ期睡眠、慢波睡眠、快速眼动睡眠相、睡眠潜伏期、快速眼动睡眠相潜伏期、长、短觉醒次数比较,差异均无统计学意义(P>0.05)。治疗后结合组患者睡眠效率明显升高(P<0.05),总睡眠时间有升高趋势(P>0.05);中药组此两项有升高趋势(P>0.05)。结论加味逍遥散或加味逍遥散联合舒乐安定片可以明显改善患者主观睡眠质量,加味逍遥散联合舒乐安定可提高睡眠效率。 |
| 英文摘要: |
| Objective To subjectively and objectively assess the effect of Jiawei Xiaoyao Powder(JXYP)on sleep in patients with psychological stress insomnia.MethodsA randomized controlled study was conducted in 33 patients with psychological stress insomnia.They were assigned to 4 groups,4 in the TCM group treated with JXYP,5 in the Western medicine(WM)group treated with Estazolam,9 in the integrated medicine(IM)group treated with JXYP plus Estazolam,and 10 in the control group treated with placebo.Quality of sleep in patients was assessed subjectively and objectively before treatment and 6 weeks after treatment by Pittsburgh sleep quality index(PSQI),self-rating scale of sleep(SRSS)and polysomnography(PSG),respectively.ResultsSubjective assessment on sleep showed that after 6-week treatment,the scores of PSQI and SRSS remarkably reduced in the TCM,IM and control groups(P<0.05),while the decrease was insignificant in the WM group(P>0.05),but no significant difference between groups was shown.The objective assessment by PSG showed that no significant change was found after treatment in parameters of total sleep time(TST),sleep time of phase 1 and 2,slow wave phase,rapid-eye-movement(REM)phase,sleep latency,REM sleep latency,also in long waking and short waking times in all group(P>0.05),but a significant increase of sleep efficacy(P<0.05)and an increasing trend of TST(P>0.05)were shown in the IM group,and an increasing trend of both in the TCM group(P>0.05).ConclusionJXYP,combined with or without Estazolam,can improve the quality of sleep subjectively,and the combination of the two could enhance the efficacy of sleep in patients with psychological stress insomnia. |
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