| 刘维,刘晓亚,张宏博,王熠,张磊,张威.中西医结合治疗系统性红斑狼疮的远期疗效[J].中国中西医结合杂志,2009,(3):219-221 |
| 中西医结合治疗系统性红斑狼疮的远期疗效 |
| Long-term Efficacy of Integrative Medicine for Treatment of Systemic Lupus Erythematosus |
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| DOI： |
| 中文关键词: 系统性红斑狼疮 中西医结合 远期疗效 |
| 英文关键词:systemic lupus erythematosus integrative TCM and Western medicine long-term therapeutic efficacy |
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| 中文摘要: |
| 目的观察中西医结合治疗系统性红斑狼疮(SLE)的远期疗效。方法采用随机分组的方法,治疗组74例用中药解毒诸法联合激素治疗,对照组74例只用激素治疗,观察两组稳定期时间、SLE临床表现、24h尿蛋白定量、系统性红斑狼疮疾病活动指数(SLEDAI)积分及补体C3等。结果治疗5年后两组症状(关节炎、浆膜炎、发热)组间比较差异有统计学意义(P<0.05)。第5年稳定期时间(天)治疗组(305.41±14.32)大于对照组(190.22±15.43);SLEDAI积分治疗组(8.28±4.12)低于对照组(12.79±5.43);24h尿蛋白(g/24h)治疗组(0.18±0.01)低于对照组(0.31±0.06);补体C3(g/L)治疗组(0.98±0.35)高于对照组(0.73±0.34);以上各指标治疗组改善优于对照组,差异皆有统计学意义(P<0.05)。不良反应发生治疗组15例,对照组62例,两组比较差异有统计学意义(P<0.05)。结论中西医结合治疗可减少脏器损害,延长SLE稳定期的持续时间,体现了治未病的思想。 |
| 英文摘要: |
| Objective To investigate the long-term efficacy of integrative medicine in treating systemic lupus erythematosus(SLE).MethodsAdopting randomized grouping method,the SLE patients were assigned to two groups,74 in each group,the treatment group treated by combined hormonotherapy with Chinese drugs for detoxifying,and the control group treated by hormonotherapy alone.The period of the stable phase and active phase,clinical manifestations,24-h urinary protein,systemic lupus erythematosus disease activity index(SLEDAI)score and complement 3(C3),etc.were observed.ResultsAfter 5-year treatment,the clinical manifestations,including arthritis,hydrohymenitis and fever revealed between groups were significantly different(P<0.05).Comparison between groups in the 5th year of observation showed that the treatment group had a longer time of the stable phase(305.41±14.32 days);lower SLEDAI scores(8.28±4.12)and 24-h urinary protein(0.18±0.01)g,and a higher level of C3(0.98±0.35 g/L)than those in the control group(190.22±15.43 days,12.79±5.43 scores,0.31±0.06 g and 0.73±0.34 g/L),respectively,with statistical significances(P<0.05).Adverse reactions occurred in 15 cases in the treatment group and 62 cases in the control group,also with significant difference between groups(P<0.05).ConclusionThe combined therapy of Chinese and Western medicine can prolong the stable phase time and shorten the lasting period of SLE in patients,which embodies the view of "treating disease before its onset". |
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