肝炎后肝硬化中医证候与疾病信息相似度分析

基金项目:上海市教育委员会资助项目(No.06CZ008);上海市教委E研-究院建设计划资助项目(No.E03008);上海市科委中医临床疗效评价方法研究项目(No.06DZ19728);国家科技支撑计划中医药诊疗与评价技术研究项目(No.2006BAI08B02-06);中国博士后基金资助项目(No.20070420106)

作者	单位
苏越	上海中医药大学中医复杂系统研究中心
王磊	上海中医药大学附属曙光医院肝病研究所
张华	上海中医药大学附属曙光医院肝病研究所
张琴	上海市公共卫生临床中心
陆奕宇	上海中医药大学中医复杂系统研究中心
刘平	上海中医药大学,上海市高校中医内科学E研究院
苏式兵	上海中医药大学中医复杂系统研究中心

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中文摘要:

目的探讨肝炎后肝硬化中医证候与临床症状及生物学指标间的相似性。方法在对变量进行归一化处理的基础上,采用夹角余弦、相关系数、相似度D及谱图相似度等4种相似度分析方法对279例肝炎后肝硬化患者临床表征信息(症状)、生物学指标和证候进行相似性分析。结果获得相应的相似度矩阵,以分别反映中医证候和症状与生物学指标之间的相似性,4种方法得到的结果基本一致,相似度D法、夹角余弦法和谱图相似度法与传统的相关系数法相比匹配度显著提高,灵敏度高、取舍定量合理,方法可靠,较切合临床实际。结论通过相似度分析方法所得证候与临床信息间的相似关系与临床实际基本相符。该技术可简化临床指标数量,为寻找中医证候特征提供简捷、可靠的方法。

英文摘要:

Objective To explore the similarity between traditional Chinese medicine(TCM) syndromes and clinical symptoms and biological parameters in patients with post-hepatitis cirrhosis(PHC).Methods After the variants had been normalized,4 methods for similarity analysis,i.e.method of cosine distance,correlation coefficient,D and spectral similarity,were used to analyze the similarity of clinical characteristic information(symptoms),biological parameters and TCM syndromes obtained from 279 patients with PHC.Results The corresponding similarity matrixes were used to reflect the similarity between TCM syndromes and symptoms and biological parameters respectively,results obtained by the 4 methods were basically identical.As compared with the traditional correlation coefficient analysis,the other three methods showed a higher level of matching,sensitivity,rationality in quantitative accepting-rejecting and reliability,and were more accordant with clinical practice.Conclusion The resemblance between TCM syndromes and clinical information on disease obtained from similarity analysis is basically in accordance with the clinical practice,so,the technique could be taken as a method for finding the characteristics of TCM syndrome with simplified clinical parameters.

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