理虚解郁方治疗慢性疲劳综合征75例疗效观察

作者	单位
张振贤	上海中医药大学附属岳阳中西医结合医院中医内科
吴丽丽	上海中医药大学附属岳阳中西医结合医院中医内科
陈敏	上海中医药大学附属岳阳中西医结合医院中医内科
张维佳	上海中医药大学附属岳阳中西医结合医院中医内科
仇璐娜	上海中医药大学
夏翔	上海瑞金医院中医内科

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中文摘要:

目的探讨对慢性疲劳综合征(chronic fatigue syndrome,CFS)有效的中医疗法。方法选取2007年3月—2008年4月符合纳入标准的CFS患者75例,分为两组;治疗组40例,采用中药理虚解郁方(由黄芪30g葛根30g党参15g丹参10g景天三七15g仙灵脾10g郁金10g石菖蒲10g,统一由自动煎药机煎汁,200mL/包,每次1包,早晚2次口服)。对照组35例,给予口服维康复10mg,2次/d,三磷酸腺苷20mg,3次/d,谷维素(上海华氏)20mg,3次/d。观察两组血清免疫球蛋白(IgG、IgA、IgM、IgE)及血T、B、NK、Th、Ts细胞含量及CD4/CD8等实验室指标。结果治疗后两组疲劳积分比较,差异有统计学意义(P<0.01);治疗组治疗后SCL-90各因子评分及总评分较治疗前降低(P<0.01);治疗前后两组体液免疫IgG、IgA、IgM、IgE比较,差异均无统计学意义(P>0.05);两组治疗前Th及Ts细胞含量比较,差异无统计学意义(P>0.05);治疗组治疗后Th细胞、Ts细胞含量升高,CD4/CD8比值降低,与治疗前比较,差异均有统计学意义(P<0.05);与对照组治疗后比较,差异亦有统计学意义(P<0.05)。结论中药理虚解郁方治疗CFS有明显的优越性。

英文摘要:

Objective To investigate the effective Chinese medicine treatment of chronic fatigue syndrome (CFS). Methods Seventy-five CFS patients meeting the inclusive criteria were enrolled from March 2007 to April 2008 and randomized into two groups. The 40 patients in the treated group were orally treated with Lixu Jieyu Recipe (LJR,consisted of milkvetch root 30 g,kudzuvine root 30 g,asiabell root 15 g,red sage root 10 g,aizoon stonecrop 15 g,epimeddium herb 10 g,curcuma root 10 g,and grassleaved sweetflag rhizome 10 g,made into 200 mL of decoction),for 100 mL twice a day. The 35 patients in the control group were treated with vitamin B tablets (10 mg twice a day),adenosine triphsphate (ATP,20 mg,thrice a day) and Oryzanol tablets (20 mg thrice a day). The laboratory indicators including serum immunoglobulins (IgG,IgA,IgM,IgE),blood immune cells,as T-cells (Th and Ts),B-cells,natural killer cells,as well as CD4/CD8 ratio were measured before and after 3-month treatment. Results After treatment the difference in scores of fatigue symptoms between the two groups was significant (P<0.01),the scores of various SCL-90 factors and the total score significantly reduced in the treated group after treatment (P<0.01). Levels of the immunoglobulins measured before treatment were in an equilibrium state,they all were unchanged after treatment in both groups (P>0.05),and showed no significant difference between groups either before or after treatment. As for the immune cells,significant increase of the lowered Th,Ts cells,and decrease of CD4/CD8 ratio were found in both groups after treatment (P<0.05),but the improvement was more significant in the treated group,so the difference between groups in these indices after treatment also showed statistical significance (P<0.05). Conclusion LJR shows superiority in treating CFS.

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