参芪扶正注射液对乳腺癌患者免疫功能的影响

作者	单位
李洪胜	广州医学院附属肿瘤医院胸外科
杨波	广州医学院附属肿瘤医院胸外科
苏旭春	广州医学院附属肿瘤医院胸外科
成拯	广州医学院附属肿瘤医院胸外科
卢敏莹	广州医学院附属肿瘤医院胸外科
祁岩超	广州医学院附属肿瘤医院胸外科
刘城林	广州医学院附属肿瘤医院胸外科
何伟星	广州医学院附属肿瘤医院胸外科
钱朋飞	广州医学院附属肿瘤医院胸外科
王远东	广州医学院附属肿瘤医院胸外科

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中文摘要:

目的从细胞及分子水平探讨参芪扶正注射液对乳腺癌患者免疫功能损害的修复作用及机制。方法77例经病理诊断为乳腺癌的患者分为3组,A组22例仅用手术治疗,B组26例术前化疗加手术,C组29例术前化疗加参芪扶正注射液加手术,另设D组22例为良性肿瘤对照。用流式细胞仪检测各组患者肿瘤组织、引流淋巴结中CD83、CD80、CD86蛋白表达水平。结果A、B、C组癌组织、腋窝淋巴结细胞CD83、CD80、CD86蛋白表达水平比D组明显降低(P<0.05);B组除腋窝淋巴结细胞CD83外均低于A组,C组除腋窝淋巴结细胞CD83外均高于B组(P<0.05,P<0.01),其腋窝淋巴结细胞CD80高于A组(P<0.05)。结论肿瘤及化疗对机体免疫功能产生不良影响,参芪扶正注射液可能参与激活树突状细胞功能,上调共刺激分子水平,帮助修复机体的免疫损伤。

英文摘要:

Objective To investigate the effect and mechanism of Shenqi Fuzheng Injection (SFI) in repairing immune function of organism at cellular and molecular levels. Methods Seventy-seven patients with pathologically confirmed diagnosis of breast cancer were assigned to three groups,the 22 patients in group A received surgical operation only;the 26 in group B were treated with surgical operation and chemotherapy;and to the 29 in group C,both chemotherapy and SFI were given after surgical operation. Besides,a group D with 22 patients with benign tumor was set up for control. The protein expressions of CD83,CD80 and CD86 in all patients′ tumor tissue and axillary lymph node were detected by flow cytometry before and after treatment. Results Levels of CD83,CD80 and CD86 in both tumor tissue and lymph node of cancer patients were significantly lower than those in the control (P<0.05);and those in group B were significantly lower than in group A (P<0.05,P<0.01);but no significant difference was found in comparing the corresponding indices between group A and group C (P>0.05). Conclusion The immune function of tumor patients could be impaired by tumor and chemotherapy definitely,and SFI could give aid to the repairing of immunity by way of participating in the activation of dendritic cells and the up regulation of co-stimulus molecules.

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