| 刘存根,冷大跃,刘欢,贺菊乔.清胰汤预防经内镜逆行性胰胆管造影术后所致胰腺炎和高淀粉酶血症的临床研究[J].中国中西医结合杂志,2009,(7):607-610 |
| 清胰汤预防经内镜逆行性胰胆管造影术后所致胰腺炎和高淀粉酶血症的临床研究 |
| Effect of Qingyi Decoction in Preventing Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis and Hyperamylasemia |
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| DOI： |
| 中文关键词: 清胰汤 经内镜逆行性胰胆管造影术 胰腺炎 高淀粉酶血症 预防 |
| 英文关键词:Qingyi Decoction endoscopic retrograde cholangiopancreatography pancreatitis hyperamylasemia prevention |
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| 中文摘要: |
| 目的探讨清胰汤对经内镜逆行性胰胆管造影术(ERCP)后所致胰腺炎和高淀粉酶血症的预防作用。方法将行ERCP术的125例患者,采用随机数字表法分为中药组(39例)、奥曲肽组(42例)和对照组(44例),分别于术前及术后4h给予清胰汤、奥曲肽及常规给予抗生素治疗;比较3组术后血淀粉酶、C反应蛋白(CRP)、白细胞介素-10(IL-10)的变化及术后胰腺炎和高淀粉酶血症发生率。结果(1)术后4、24h血淀粉酶值(U/L)中药组(132.03±75.29,153.15±78.69)和奥曲肽组(134.74±22.24,148.50±79.37)较对照组(241.27±137.04,286.89±133.77)为低(P<0.05)。(2)术后24hCRP值(mg/L)中药组(11.05±3.57)和奥曲肽组(12.48±3.80)也较对照组(17.70±4.93)为低(P<0.05);术后24hIL-10值(ng/L)中药组(105.00±31.85)较奥曲肽组(77.98±33.13)和对照组(75.98±30.99)显著升高(P<0.01)。(3)中药组、奥曲肽和对照组胰腺炎的发生率分别为2.6%(1/39)、0、11.4%(5/44);高淀粉酶血症发生率分别为28.2%(11/39)、21.4%(9/42)、56.8%(25/44),中药组、奥曲肽组高淀粉酶血症发生率低于对照组(P<0.05)。结论清胰汤能降低血CRP和上调IL-10值,抑制炎症反应,并能降低术后血淀粉酶值,减少高淀粉酶血症的发生。 |
| 英文摘要: |
| Objective To explore the preventive effect of Qingyi Decoction(QYD)on post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis and hyperamylasemia.Methods One hundred and twenty-five patients scheduled to receive ERCP were randomized by the digital table into three groups,two were medicated respectively with QYD(39 cases)and octreotide(42 cases),the other one was untreated for control(44 cases).Changes of blood levels of amylase,C-reactive protein(CRP),and interleukin-10(IL-10),as well as the incidence of pancreatitis and hyperamylasemia was observed and compared.Results The 4 h and 24 h post-operational blood amylase(U/L)was 132.03±75.29 and 153.15±78.69 in the QYD group,and 134.74±22.24 and 148.50±79.37 in the octreotide group,all were significantly lower than those in the control group(241.27±137.04 and 286.89±133.77),respectively.The 24 h CRP(mg/L)in both QYD and octreotide group(11.05±3.57 and 12.48±3.80)was also lower than that in the control group(17.70±4.93,P<0.05),while the 24 h IL-10(ng/L)in the QYD group(105.00±31.85)was higher than that in the octreotide group(77.98±33.13)and the control group(75.98±30.99)respectively.The incidence of pancreatitis in the QYD,octreotide,and the control group was 2.6%,0 and 11.4%,that of hyperamylasemia in them 28.2%,21.4%,and 56.8%,respectively.The occurrence rate of hyperamylasemia was lower in the QYD group and the octreotide group than in the control group(P<0.05).Conclusion QYD could lower CRP and up-regulate IL-10 level,restrain the inflammation reaction and reduce the blood amylase level in the post-ERCP period,thus reducing the incidence of hyperamylasemia. |
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