中药归参止痒方治疗血虚肝旺型老年皮肤瘙痒症的疗效及对干细胞因子与强啡肽的影响

Effect of Guishen Zhiyang Recipe for Treatment of Patients with Senile Pruritus of Blood-Deficiency and Gan-Hyperactive Syndrome Type and Its Impact on Stem Cell Factor and Dynorphin

免费下载全文查看/发表评论下载PDF阅读器

DOI：

中文关键词: 皮肤瘙痒症老年归参止痒方血虚肝旺干细胞因子强啡肽

英文关键词:pruritus senile Gwishen Zhiyang Recipe blood-deficiency and Gan hyperactive syndrome type stem cell factor dynorphin

基金项目:

作者	单位
兰东	首都医科大学附属北京朝阳医院(京西院区)皮肤科
张海燕	首都医科大学附属北京朝阳医院呼吸科呼吸基础研究室
庞宝森	首都医科大学附属北京朝阳医院呼吸科呼吸基础研究室

摘要点击次数: 1448

全文下载次数: 3

中文摘要:

目的观察养血柔肝中药归参止痒方对血虚肝旺型老年皮肤瘙痒症患者临床疗效及其对干细胞因子(SCF)及强啡肽(DYN)的影响,探讨其治疗老年皮肤瘙痒症的作用机制。方法61例患者按完全随机化抽签法分为两组。治疗组33例口服归参止痒方,对照组28例口服肤痒颗粒,两组均服药8周。观察两组症状、皮损疗效变化,采用双抗夹心ABC-ELISA法检测两组治疗前后SCF及DYN水平变化。结果治疗组剔除3例,列入统计30例中,临床痊愈20例(66.7%),明显高于对照组(10例,35.7%,P<0.05);治疗组治疗后SCF及DYN水平较治疗前明显降低(P<0.01),且低于对照组治疗后(P<0.01,P<0.05)。结论中药归参止痒方对血虚肝旺型老年皮肤瘙痒症疗效较好,可能是通过调节SCF及DYN水平,改善了影响皮肤瘙痒的炎症介质而达到治疗目的。

英文摘要:

Objective To explore the mechanism of Chinese medicinal therapy for nourishing blood and softening Gan in treating senile pruritus through observing the impact of Guishen Zhiyang Recipe(GZR)on serum levels of stem cell factor(SCF)and dynorphin(DYN)in patients suffered from the disease of blood-deficiency and Gan-hyperactive syndrome type(BDGH).Methods Sixty patients with senile pruritus were equally randomized into two groups,the patients in the treated group(33 cases)were treated by GZR,and those in the control group(28 cases)were treated by Fuyang Granule,all for 8 weeks.Changes of symptoms and skin lesions as well as blood levels of SCF and DYN were observed before and after treatment.Results Three patients were rejected from the treated group.Twenty patients in the treated group were cured after treatment,the cure rate being 66.7%,which was significantly higher than that in the control group(10 patients,35.7%,P<0.05).Levels of SCF and DYN in the treated group significantly lowered after treatment(all P<0.01),and were lower than those in the control group(P<0.05 and P<0.01,respectively).Conclusion GZR shows favorite effect in treating senile pruritus of BDGH type and it may be achieved by regulating SCF and DYN levels to improve the pruritus associated inflammatory media.

关闭