桂龙通络胶囊与泼尼松合用治疗慢性炎性脱髓鞘性多发性神经病30例

Clinical Observation on Treatment of 30 Patients with Chronic Inflammatory Demyelinating Polyneuropathy by Guilong Tongluo Capsule Combined with Prednisone

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中文关键词: 慢性炎性脱髓鞘性多发性神经病桂龙通络胶囊中西医结合治疗

英文关键词:chronic inflammatory demyelinating polyneuropathy Guilong Tongluo Capsule integrated Chinese and Western medical treatment

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作者	单位
胡军勇	河北以岭医院
陈金亮	河北以岭医院
张志慧	河北以岭医院

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中文摘要:

目的评价桂龙通络胶囊治疗慢性炎性脱髓鞘性多发性神经病的疗效。方法将60例本病缓慢进展型患者随机分为两组,治疗组30例采用泼尼松并用中药桂龙通络胶囊治疗,对照组30例采用泼尼松治疗,共3个月,比较两组治疗前后四肢肌力、肢体功能状况、感觉障碍,日常生活能力(ADL)积分及神经传导速度变化。结果治疗组总有效率90.0%(27/30),对照组为70.0%(21/30),两组比较差异有统计学意义(χ2=14.82,P<0.01)。在下肢肌力增加、四肢运动功能及感觉障碍改善、ADL积分及尺神经运动传导速度和腓总神经运动、感觉传导改善方面治疗组明显优于对照组(P<0.05,P<0.01)。结论桂龙通络胶囊并用泼尼松治疗慢性炎性脱髓鞘性多发性神经病的临床疗效较单纯应用泼尼松治疗为优。

英文摘要:

Objective To observe and evaluate objectively the clinical effect of Guilong Tongluo Capsule(GTC)in treating chronic inflammatory demyelinating polyneuropathy(CIDP).Methods Sixty CIDP patients were equally randomized into two groups.The treated group was administered with GTC and prednisone,while the control group with prednisone alone.Changes before and after 3-month treatment in terms of muscle force,functional and sensory disturbance of extremities,as well as scoring by Activity of Daily Living Scale(ADL)and electromyogram(EMG)for nerve conduction velocity were observed and compared.Results The total effective rate gained in the treated group and the control group was 90.0%(27/30)and 70.0%(21/30)respectively,showing significant difference between them(χ2=14.82,P<0.01).The improvement in the treated group was superior to the control group in muscle force of lower limb,motive and sensory function of extremities,ADL scores and motive function of ulnar nerve(P<0.05,P<0.01).Conclusion The curative effect of GTC combined with prednisone in treating CIDP was better than that of prednisone alone.

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