| 蒋卫民,赖仁胜,陈晓虎,唐蜀华.载脂蛋白E基因多态性对血脂康胶囊调脂作用的影响[J].中国中西医结合杂志,2009,(8):688-691 |
| 载脂蛋白E基因多态性对血脂康胶囊调脂作用的影响 |
| Influence of Apolipoprotein E Gene Polymorphism on the Lipid Regulation by Xuezhikang Capsule |
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| DOI： |
| 中文关键词: 载脂蛋白E 基因多态性 血脂康胶囊 |
| 英文关键词:apolipoprotein E gene polymorphism Xuezhikang Capsule |
| 基金项目:江苏省自然科学基金资助课题(No.BK2005162) |
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| 中文摘要: |
| 目的探讨载脂蛋白E(ApoE)基因多态性对血脂康胶囊调脂作用的影响。方法采用基因测序法检测74例高脂血症患者ApoE基因多态性,并检测给予血脂康胶囊治疗6周前后血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标,分析ApoE基因多态性与各血脂指标变化值之间的关系。结果含ε2等位基因型(E2/E2+E2/E3)TG降低幅度明显大于E3/E3型和含ε4等位基因型(E3/E4+E4/E4);含ε4等位基因型(E3/E4+E4/E4)HDL-C升高幅度明显低于含ε2等位基因型(E2/E2+E2/E3)和E3/E3型。结论ApoE基因多态性对血脂康调脂作用具有影响,它主要体现在不同的ApoE基因表型TG降低幅度和HDL-C升高幅度存在差异。 |
| 英文摘要: |
| Objective To explore the influence of apolipoprotein E (ApoE) gene polymorphism on the lipid metabolism regulatory effect of Xuezhikang Capsule (XZKC). Methods ApoE polymorphism of 74 patients with hyperlipidemia was detected by gene sequencing method,and their plasma levels of total cholesterol (TC),triglyceride (TG),high-and low-density lipoprotein cholesterol (HDL-C and LDL-C) were determined before and after they received a 6-week treatment of XZKC,for analyzing the relationship between ApoE gene polymorphism and the changes of various blood lipids associated indices. Results The effect of XZKC on reducing TG in the ε2 allele (E2/E2 and E2/E3 genotypes) was higher than that in the E3/E3 genotypes and ε4 allele (E3/E4 and E4/E4 genotypes),while on increasing HDL-C,it showed more effect in the ε4 allele (E3/E4 and E4/E4 genotypes) than that in the ε2 allele (E2/E2 and E2/E3 genotypes) and E3/E3 genotypes. Conclusion Patients′ ApoE gene polymorphism could influence the lipid regulatory effect of XZKC,embodying mainly by raising HDL-C and reducing TG in patients with different ApoE genotypes to different extents. |
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