| 陈章强,洪浪,王洪,尹秋林,赖珩莉,陆林祥.丹红注射液对急性冠脉综合征患者介入治疗后血小板活化和炎症因子的影响[J].中国中西医结合杂志,2009,(8):692-694 |
| 丹红注射液对急性冠脉综合征患者介入治疗后血小板活化和炎症因子的影响 |
| Effect of Danhong Injection on Platelet Activation and Inflammatory Factors in Patients of Acute Coronary Syndrome after Intervention Therapy |
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| DOI： |
| 中文关键词: 急性冠脉综合征 介入治疗 血小板活化 炎症反应 丹红注射液 |
| 英文关键词:acute coronary syndrome intervention therapy platelet activation inflammatory reaction Danhong Injection |
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| 中文摘要: |
| 目的探讨丹红注射液对急性冠脉综合征(ACS)患者介入治疗后血小板活化和炎症因子的影响。方法100例ACS患者随机分为丹红注射液治疗组(简称丹红组,50例)和常规治疗组(简称常规组,50例)。常规组在经皮冠状动脉介入治疗(PCI)术后给予阿司匹林、氯比格雷、β受体阻滞剂、血管紧张素转化酶抑制剂等治疗2周。丹红组在常规治疗组基础上静脉滴注丹红注射液治疗2周,并与对照组进行比较。两组病例在PCI术前和术后次日清晨分别空腹抽肘静脉血用流式细胞仪测定血小板活化指标P选择素(CD62p)和糖蛋白(GP)Ⅱb/Ⅲa受体复合物的表达水平;用散射比浊法测定血浆纤维蛋白原C(FIB-C)的水平;用乳胶免疫增强比浊法测定血清高敏C反应蛋白(hs-CRP)水平。并选择健康体检者40名作对照。结果ACS患者PCI术前血清CD62P、GPⅡb/Ⅲa、FIB-C和hs-CRP较健康对照组明显升高(均P<0.01);PCI术后上述指标较术前均有显著性增高(P<0.05,P<0.01);治疗2周后,两组患者的CD62p、GPⅡb/Ⅲa、FIB-C和hs-CRP表达水平较PCI术前均有不同程度的下降(P<0.05或P<0.01),与常规治疗组比较,丹红治疗组差异均有统计学意义(P<0.05)。结论丹红注射液可以抑制ACS患者PCI术后血小板活化和炎症反应。 |
| 英文摘要: |
| Objective To explore the effect of Danhong Injection (DHI) on platelet activation and inflammatory factors in patients of acute coronary syndrome (ACS) after intervention therapy. Methods One hundred ACS patients were randomly assigned to the DHI group and the control group equally. Both were treated with the conventional treatment,including aspirin,clopidogrel,β-receptor blocker,angiotensin converting enzyme inhibitor,etc. for 2 weeks after percutaneous coronary intervention (PCI),and to the patients in the DHI group,intravenous dripping of DHI was given simultaneously. Fasting venous blood of patients were collected before PCI and on the next morning of PCI to determine the platelet activation indices,expression of CD62p and receptor complex of glucose protein (GP)Ⅱb/Ⅲa by flow cytometry;plasma fibrinogen C (FIB-C) by scattering turbidimetry,and serum high-sensitivity C-reactive protein (hs-CRP) with emulsoid immuno-enhancing turbidimetric test kit. The outcomes were compared with those determined in 40 healthy persons for control. Results Serum levels of CD62p,GPⅡb/Ⅲa,FIB-C and hs-CRP in ACS patients were significantly higher than those in the healthy control (all P<0.01),and those were significantly higher after PCI than before PCI (P<0.05 or P<0.01). After being treated for 2 weeks,the 4 platelet activation indices were lowered to different extent in both groups,but the lowering in the DHI group was more significant than that in the control group (P<0.05). Conclusion DHI can inhibit the platelet activation and inflammatory reaction in ACS patients after PCI. |
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