辛夷挥发油纳米脂质体滴鼻剂治疗儿童变应性鼻炎的临床观察

作者	单位
吴敏	上海交通大学医学院附属新华医院中医科
张婧延	上海中医药大学附属龙华医院
张欣	上海交通大学医学院附属新华医院中医科
倪菊秀	上海交通大学医学院附属新华医院中医科
路薇薇	上海静安区中心医院
丁丽凤	上海交通大学医学院附属儿童医学中心
李战

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中文摘要:

目的研究辛夷挥发油纳米脂质体滴鼻剂对儿童变应性鼻炎的临床疗效。方法采用平行对照方法,选择变应性鼻炎患儿191例,随机分成两组。观察组给予辛夷挥发油纳米脂质体滴鼻剂治疗,对照组给予西替利嗪片治疗。治疗3周后观察两组的临床疗效、主要症状、体征及中医证候积分、外周血嗜酸性粒细胞(EOS)的变化。结果治疗后临床总有效率观察组为94.84%,对照组为78.72%,两组比较,差异有统计学意义(χ2=15.82,P<0.05);与对照组比较,观察组主要症状(喷嚏、鼻塞)、体征(鼻黏膜水肿、苍白)差异有统计学意义(P<0.05),观察组EOS计数较治疗前明显下降(P<0.05);对照组治疗前后无明显变化。结论辛夷挥发油纳米脂质体对于儿童变应性鼻炎有治疗作用,并可能是通过降低血EOS计数实现的。

英文摘要:

Objective To observe the clinical efficacy of Flos Magnoliae volatile oil nano-liposome nasal drops (FMO) in treating pediatric allergic rhinitis (PAR). Methods Adopting parallel controlled method,the 191 patients with PAR were randomized into two groups. The observation group was treated with FMO,and the control group with Cetirizine. The clinical efficacy,main symptoms,signs,syndromes scores of Chinese medicine,and peripheral eosinophil (EOS) count were observed after 3-week treatment. Results In the observation group,the total effective rate was 94.84%,which was higher than that in the control group (78.72%);the effective rate on alleviating main symptoms (sneezing,nasal obstruction),signs (nasal mucosa edema,pallor) and the EOS count were significantly lowered,all were better than those in the control group (P<0.05). Conclusion FMO has some positive effects on PAR,it might be realized by lowering the peripheral EOS.

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