推拿对女性更年期综合征患者内分泌功能的影响

作者	单位
金涛	北京按摩医院
韩丽娟	北京按摩医院
沈艳红	北京按摩医院
曲怡	北京按摩医院
阮祥燕	北京市妇产医院内分泌科
王娟	北京市妇产医院内分泌科

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中文摘要:

目的探讨运用中医推拿"补肾活血法"治疗更年期综合征的临床疗效及对内分泌的影响。方法将更年期患者60例随机分为两组。推拿组40例,采用推拿"补肾活血法",隔日1次,每次20min,1个月为1个疗程,2个疗程后统计疗效。对照组20例,采用激素替代疗法(倍美力,0.625g,每天1次口服),2个月后观察疗效。分别于治疗前后检测血清雌二醇(E2)、促卵泡刺激素(FSH)、促黄体生成激素(LH)水平;观察治疗前后Kupperman指数变化情况。结果Kupperman指数:推拿组治疗前后分别为30.71±8.43、8.21±5.14,对照组治疗前后分别为24.32±5.44、5.92±3.58,两组差值(推拿组22.50±8.14,对照组18.40±4.50)比较,差异有统计学意义(t=2.52,P=0.014),推拿组较对照组明显降低;推拿组E2(ng/L)治疗前后分别为20.23±20.78、54.34±24.26(t=-2.73,P=0.006),对照组治疗前后分别为16.15±24.40、40.61±81.54(t=-1.72,P=0.086),两组差值比较差异无统计学意义(t=-1.12,P=0.263);治疗后对照组FSH降低程度[差值(13.16±11.29)mIU/mL]大于推拿组〔差值(4.92±4.26)mIU/mL,t=-2.49,P=0.013〕,治疗后对照组LH降低程度[差值(10.37±9.21)mIU/mL]大于推拿组[(0.17±2.42)mIU/mL],差异有统计学意义(t=-2.38,P=0.017)。结论推拿手法对于女性更年期综合征患者的Kupperman指数评价的13项主要症状均有明显的改善作用,并能显著提高E2水平。

英文摘要:

Objective To explore the therapeutic effect of Chinese medicinal massage with nourishing-Shen and activating-blood manipulation in treating women with climacteric syndrome and its influence on endocrinal function.Methods Sixty patients were assigned to two groups,the 40 patients in the treated group were treated by Chinese medicinal massage for 20 min once every other day;the 20 patients in the control group were treated by hormone replacement therapy with Premarin 0.625 g,once daily by oral taking.The therapeutic efficacy was evaluated after two-month treatment by changes of serum levels of estradiol(E2),follicular stimulating hormone(FSH),luteinzing hormone(LH),and Kupperman index before and after treatment.Results Kupperman index showed that the total symptom score in the treated group was improved from 30.71±8.43 scores before treatment to 8.21±5.14 scores after treatment,with a decrement of 22.50±8.14 scores,which was higher than that in the control group,from 24.32±5.44 scores to 5.92±3.58 scores,with a decrement of 18.40±4.50 scores,the difference between them was statistically significant(t=2.52,P=0.014).The serum level of E2 increased in both groups significantly after treatment,from 20.23±20.78 ng/L to 54.34±24.26 ng/L in the treated group(t=-2.73,P=0.006),and from 16.15±24.40 ng/L to 40.61±81.54 ng/L in the control group(t=-1.72,P=0.086),but the difference between groups was statistical insignificant(t=-1.120,P=0.263).As for levels of FSH and LH,their decrements in the control group(13.16±11.29 mIU/mL and 10.37±9.21 mIU/mL)were larger than those in the treated group(4.92±4.26 mIU/mL and 0.17±2.42 mIU/mL),respectively(t=-2.49,P=0.013;t=-2.38,P=0.017).Conclusion Chinese medicinal massage manipulation could improve the Kupperman index of all the 13 symptoms in women with climacteric syndrome,and increase the E2 level in serum.

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