鸡血藤复方治疗再生障碍性贫血66例30年随访

目的评价再生障碍性贫血(简称再障)经鸡血藤复方治疗后的长远期结局。方法采用通信联系早年(1976—1994年)鸡血藤复方及丙酸睾酮(阳虚时加用)治疗有效的110例再障患者,收集其目前健康、工作状况,复发和并发症。同时将获得信息反馈的66例患者与近期初诊的13例再障患者以及36名健康人作了对比。结果获得66例患者的信息反馈,66例平均血细胞计数:WBC4·7×109/L,N(中性粒细胞计数)2·5×109/L,Hb121·2g/L,血小板(BPC)109·5×109/L,骨髓造血组织平均72·7%,与初诊组比较差异均有统计学意义(P<0·01);SF-36积分与健康人比较差异无统计学意义(P>0·05)。66例随访者中处于学龄期30例,接受教育17例(56·7%);治疗后结婚24例,加上原已成家的26例和8例在校学生,治疗后家庭完善率达87·9%(58/66);参加工作43例(65·2%)。死亡4例;复发7例(10·6%);合并症5例(7·6%)。结论再障可以用鸡血藤复方及丙酸睾酮治愈,有很好的药物安全性。患者治愈后可完全融入社会,过着正常人的生活与工作。

英文摘要:

Objective To assess the long-term therapeutic effect of Spatholobus Composite (SSC) for treatment of aplastic anemia (AA).Methods A follow-up study was carried on 110 AA patients,who were successfully treated by SSC and testosterone propionate from 1976 to 1994,by correspondence,the information regarding blood cell count,condition of health and labor,as well as incidence of relapse and complications were collected,and the data from 66 patients response to the correspondence were compared with those of 36 healthy persons and 13 recently visited AA patients.Results In the 66 AA patients,the average blood cell counts were WBC:4.7×109/L,hemoglobin 121.2 g/L,platelet 109.5×109/L,neutrophilic granulocytes 2.5×109/L,and their mean hemopoietic tissue in bone marrow 72.7%,all were significantly different to those in the recent visitors (P<0.01);SF-36 scoring showed insignificant difference between the patients and the healthy person (P>0.05).Out of the 66 patients,17 of the 30 school-aged (56.7%) have schooling;the family consummative rate was 87.9% (58/66),including 24 got married after curing,26 had already married before illness and 8 at school students;43 (65.2%) have got job;4 died.The incidence of recurrence was 10.6% (7/66),and the complication occurred in 7.6% (5/66).Conclusions The AA patients could be cured by SSC and testosterone propionate,which is a remedy with safety.Cured patients could go into society harmoniously and have their own regular life and job.

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