| 张维怡,黄光英,刘洁,张明敏,王伟.针刺对多囊卵巢综合征大鼠不孕的影响[J].中国中西医结合杂志,2009,(11):997-1000 |
| 针刺对多囊卵巢综合征大鼠不孕的影响 |
| Influences of Acupuncture on Infertility of Rats with Polycystic Ovarian Sydrome |
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| DOI： |
| 中文关键词: 针刺 多囊卵巢综合征 着床 促排卵 子宫内膜容受性 |
| 英文关键词:acupuncture polycystic ovarian syndrome implantation ovulation induction endometrial receptivity |
| 基金项目:国家自然科学基金重大研究计划项目(No.90209009);国家973重大研究计划项目资助(No.2006CB504502) |
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| 中文摘要: |
| 目的观察针刺对多囊卵巢综合征(PCOS)大鼠不孕的影响,并探讨其作用机制。方法24日龄雌性大鼠颈背部皮下注射脱氢表雄酮(DHEA)的麻油溶液制作PCOS大鼠模型,对照组同期皮下注射麻油剂。PCOS大鼠随机分为模型组、针刺组。模型组不作任何处理,针刺组于80日龄起行针刺治疗(关元、中极、三阴交、子宫穴,每天1次,连续治疗5天),各组大鼠治疗后留取双侧卵巢和子宫标本观察,采用放免法(RIA)检测血清性激素。结果与模型组比较,针刺组大鼠胚泡着床率和平均着床胚泡数明显升高(P<0·05);血清睾酮(T)、雌二醇(E2)水平显著降低(P<0·05),而卵泡刺激素(FSH)、黄体生成素(LH)、孕酮(P4)水平差异无统计学意义(P>0·05);卵巢湿重显著降低(P<0·05),子宫腺体、腺腔的等效直径、面积和腺/间质面积比,以及子宫内膜平均厚度均显著增加(P<0·05)。结论针刺能下调血清T、E2水平,改善卵巢和子宫的发育,促进排卵,提高子宫内膜容受性,促进胚泡着床。 |
| 英文摘要: |
| Objective To observe the effect and mechanism of acupuncture on infertility of rats with polycystic ovarian syndrome (PCOS).Methods PCOS rat model was induced by subcutaneous injection of oil solution of dehydroepiandrosterone (DHEA) in immature (24-day-old) female rats for continuous 20 days.Rats for control were given with same dose of oil for instead.PCOS rats were randomly divided into the model group untreated and the acupuncture group treated by needling acupoints of Guanyuan (CV4),Zhongji (CV3),Sanyinjiao (SP6) and Zigong (CX-CA1),15 min once a day for 5 continuous days,starting from the 80th day after birth.All rats were sacrificed at terminal of the treatment,their uterus and bilateral ovaries were dissected for observation and blood levels of sex hormones were measured.Results Compared with the model group,the number of implanted blastocyte and blastocyte implantation rate were higher and the blood levels of testosterone (T) and estradiol (E2) were lower in the acupuncture group (P<0.05);but the difference between groups in serum levels of follicular stimulating hormone,luteinzing hormone and progesterone were of statistical insignificance (P>0.05).Moreover,the wet weight of ovary was lower and the equipotent diameter and area of glandular organ and cavity,area ratio of gland and the stroma,and mean thickness of endometria were higher in the acupuncture group than those in the control group (P<0.05).Conclusion Acupuncture can conspicuously down-regulate the expressions of serum levels of T and E2,improve the development of ovaries and uterus,promote ovulation,enhance endometrial receptivity,and advance blastocyte implantation. |
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