消糜颗粒治疗HIV/AIDS患者口腔念珠菌病40例疗效观察

作者	单位
姜枫	河南中医学院第一附属医院广州中医药大学
卫淑华	河南中医学院第三附属医院
彭勃	河南省科学技术协会
郭会军	河南中医学院第一附属医院
王丹妮	河南中医学院第一附属医院
薛晓玲	河南省疾病预防控制中心
符林春	广州中医药大学

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中文摘要:

目的观察消糜颗粒治疗HIV/AIDS口腔念珠菌病的疗效。方法40例HIV/AIDS患者使用消糜颗粒治疗并与制霉菌素片治疗作对照,疗程2周,观察治疗前后临床症状、口腔念珠菌涂片镜检、培养结果,并观察服药安全性,停药后2周随访,比较复发率。结果两组治疗后口黏腻、口干、乏力、腹胀、纳呆均有改善,与治疗前比较,差异有统计学意义(P<0.05),治疗组在改善口黏腻、口干的疗效优于对照组。治疗组有效率、复发率分别为90.0%(36/40)和11.1%(4/36),对照组为72.5%(29/40)和31.0%(9/29),消糜颗粒对HIV/AIDS口腔念珠菌病的疗效优于制霉菌素片。结论消糜颗粒治疗HIV/AIDS口腔念珠菌病可改善临床症状,提高有效率、降低复发率。

英文摘要:

Objective To observe the effect of Xiaomi Granules(XMG) for treatment of HIV/AIDS oral candidiasis.Methods Forty patients in the treated group were treated by XMG and 40 patients in the control group were treated with anticandine.The therapeutic course for both groups was two weeks.Changes of clinical symptoms,oral candida microscopic examination and cultured before and after treatment as well as the safety of treatment were observed,and a follow-up study was implemented two weeks after ending medication to compare the relapse rate between groups.Results Symptoms as oral greasy-sticky,thirsty,asthenia,abdominal distension and anorexia were improved after treatment in both groups(P<0.05).The improvements of oral greasy-sticky and thirsty in the treated group were better than those in the control group(P<0.05).The effective rate and relapse rate in the treated group was 90.0%(36/40) and 11.1%(4/36) respectively,while in the control group,72.5%(29/40) and 31.0%(9/29) respectively.Conclusion XMG could improve the clinical symptoms with high efficacy and low relapse rate,shows a better effect than that of anticandine in treating HIV/AIDS oral candidiasis.

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