清胰汤对重症急性胰腺炎患者的疗效及血中肿瘤坏死因子-α和白细胞介素-6、8的影响

Effect of Qingyi Decoction in Treating Severe Acute Pancreatitis and Its Impacts on Blood Level of Tumor Necrosis Factor-α,Interleukin-6 and Interleukin-8

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中文关键词: 重症急性胰腺炎清胰汤肿瘤坏死因子-α 白细胞介素

英文关键词:severe acute pancreatitis Qingyi Decoction tumor necrosis factor-α interleukin

基金项目:

作者	单位
杨东鹰	新疆医科大学附属中医医院普外科
段绍斌	新疆医科大学附属中医医院普外科
居来提.艾力	新疆医科大学附属中医医院普外科
樊晓静	新疆医科大学附属中医医院普外科

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中文摘要:

目的观察清胰汤对重症急性胰腺炎(severe acute pancreatitis,SAP)患者的疗效及对血中肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6和IL-8的影响。方法将110例SAP患者随机分为治疗组和对照组,每组各55例。治疗组除使用清胰汤外其他治疗同对照组。观察治疗以后两组严重并发症的发生率、病死率、中转手术率、APACHEⅡ评分变化以及血中TNF-α、IL-6和IL-8浓度的变化。结果治疗组严重并发症中急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)和肠麻痹的发生率为3.6%和5.4%,对照组为12.7%和18.2%,两组差异有统计学意义(P<0.05)。治疗组治疗7d后,APACHEⅡ评分下降幅度[(8.14±2.30)分]较对照组[(3.35±2.20)分]明显,差异有统计学意义(P<0.05)。治疗组病死率、中转手术率、治疗后第7和第9天的TNF-α、IL-6和IL-8浓度明显低于对照组,差异有统计学意义(P<0.05)。结论清胰汤可通过明显降低SAP患者血中TNF-α、IL-6、IL-8浓度而显著改善患者的预后。

英文摘要:

Objective To observe the effect of Qingyi Decoction(QYD) in treating severe acute pancreatitis(SAP) and its impacts on blood levels of tumor necrosis factor-α(TNF-α),interleukin 6 and 8(IL-6 and IL-8).Methods One hundred and ten patients of SAP were equally randomized into the treated group and the control group,they were treated with the same therapeutic program excepting that QYD was given only to the treated group.The post-treatment incidence of severe complication,mortality and operation transferring rate,as well as the changes of APACHEⅡ scores and blood levels of TNF-α,IL-6 and IL-8 in patients of both groups were observed.Results The incidences of the two severe complications,acute respiratory distress syndrome and intestinal paralysis,in the treated group was 3.6% and 5.4% respectively,while in the control group,12.7% and 18.2%,showing statistical significance between groups(P<0.05).The APACHEⅡ score in the treated group decreased significantly on the 7th day,which was better than that in the control group(8.14±2.30 scores vs 3.35±2.20 scores,P<0.05).In addition,the efficacy in the treated group was also superior to that in the control group in terms of reducing mortality,operation transferring rate,and blood levels of TNF-α,IL-6 and IL-8 on the 7th and 9th day(P<0.05).Conclusion QYD could markedly improve the prognosis of SAP patients by way of lowering the blood levels of TNF-α,IL-6 and IL-8.

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