| 吴继,徐振晔,王中奇,周卫东,邓海滨,赵晓珍,白冰,王立芳.抗瘤增效方治疗晚期非小细胞肺癌的临床研究[J].中国中西医结合杂志,2010,30(2):137-140 |
| 抗瘤增效方治疗晚期非小细胞肺癌的临床研究 |
| Clinical Study on Treatment of Advanced Non-small Cell Lung Cancer with Kangliu Zengxiao Decoction |
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| DOI： |
| 中文关键词: 晚期非小细胞肺癌 抗瘤增效方 临床研究 |
| 英文关键词:advanced non-small cell lung cancer Kangliu Zengxiao Decoction clinical study |
| 基金项目:上海市重点学科建设项目资助(No.Y0302) |
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| 中文摘要: |
| 目的观察抗瘤增效方对晚期非小细胞肺癌患者的临床疗效。方法61例确诊为Ⅲa、Ⅲb、Ⅳ期非小细胞肺癌患者随机分为治疗组(化疗加中药)32例,对照组(单纯化疗组)29例,均采用NP方案化疗2个疗程,治疗组在化疗同时口服中药抗瘤增效方。结果抗瘤增效方配合化疗可改善大部分临床症状,提高中位生存期及生活质量,增加体重,减轻血液和消化系统不良反应,提高机体免疫功能,降低肿瘤标志物CEA、VEGF、CYFRA21-1的水平,但在减小和稳定病灶方面与对照组比较,差异无统计学意义。结论抗瘤增效方与化疗合用具有减毒增效作用,是治疗晚期非小细胞肺癌的有效方法之一。 |
| 英文摘要: |
| Objective To observe the effect of Kangliu Zengxiao Decoction (KLZX) in treating patients with advanced non-small cell lung cancer (NSCLC). Methods Sixty-one patients with confirmed diagnosis of NSCLC of Ⅲa-Ⅳ stage were randomly assigned to the treatment group (32 patients) and the control group (29 patients). Both groups were treated with two cycles of chemotherapy NP regimen, while KLZX was given to the treatment group additionally. Results As compared with the control group, the improvements in the treatment group was better in terms of majority of clinical symptoms, median survival time, Karnofski score and body weight, also in increasing immune function, decreasing levels of tumor marks (CEA, VEGF, CYFRA21-1) and alleviating hemopoietic and digestive adverse reactions. But the two groups showed insignificant difference in reducing tumor size and stabilizing tumor foci. Conclusion Combined use of KLZX and chemotherapy has the toxicity reducing and effect enhancing action, is one of the effective approaches for treatment of advanced NSCLC. |
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