宁心痛颗粒对冠心病气虚血瘀证患者左室舒张功能不全的影响

Effect of Ningxintong Granule in Treating Patients of Coronary Heart Disease with Left Ventricular Diastolic Dysfunction and Qi-deficiency Blood-stasis Syndrome

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中文关键词: 宁心痛颗粒益气活血法冠心病左室舒张功能不全

英文关键词:Ningxintong Granule qi-enriching and blood-activating therapy coronary heart disease left ventricular diastolic dysfunction

基金项目:江苏省中医药管理局资助项目(No.HZ07033);南京市科技局科技发展计划项目(No.200801081)

作者	单位
吴同启	南京中医药大学
顾宁	南京中医药大学第三附属医院
王芳芳	南京中医药大学
汪静	南京中医药大学第三附属医院
庞家华	南京中医药大学第三附属医院

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中文摘要:

目的观察宁心痛颗粒对冠心病气虚血瘀证患者左室舒张功能不全的影响。方法将76例冠心病气虚血瘀证左室舒张功能不全患者随机分为治疗组(40例)与对照组(36例),对照组采用常规西药治疗,治疗组在常规西药的基础上加用宁心痛颗粒(由黄芪、葛根、川芎、毛冬青、细辛制成,每包10 g)每次1包,每天3次,疗程4周。采用多普勒超声心动图检测治疗前后左室舒张功能指标舒张早期二尖瓣血流峰值(Emas)、舒张晚期二尖瓣血流峰值(Amas)及两者之比值(E/A),E峰减速度时间(DT)和等容舒张时间(IVRT),并观察临床疗效及中医证候疗效。结果治疗组Emas、E/A增加,Amas、DT、IVRT降低,与治疗前及对照组治疗后比较,差异均有统计学意义(P<0.05);中医证候疗效及临床疗效亦优于对照组。结论具有益气活血功能的宁心痛颗粒对气虚血瘀证冠心病左室舒功能不全患者具有明显改善作用。

英文摘要:

Objective To investigate the effect of Ningxintong Granule(NXTG) on left ventricular diastolic dysfunction(LVDD) in patients with coronary heart disease(CHD) of qi-deficiency and blood-stasis syndrome in Chinese medicine.Methods Seventy-six CHD patients with LVDD of qi-deficiency blood-stasis syndrome were randomized into two groups.The 36 patients in the control group were treated by Western medical conventional treatment alone,and 40 patients in the treated group were treated by NXTG(Consisting of milkvetch root,pueraria root,ligustici,ilexpuhesceus,manchurian wildginger,10 g in each package) and Western medical conventional treatment in combination,one package each time,thrice daily,4 weeks as one the rapeutic course.The left ventricular function(LVF) of all patients(including Emas,Amas,E/A,DT and IVRT) was evaluated by Doppler echocardiography before and after treatment,and the changes of clinical effectiveness and TCM syndrome effectiveness were observed.Results Compared with the control group after treatment,Emas,E/A increased,while Amas,DT,IVRT decreased showing statistical difference(P<0.05).The therapeutic effects in the treated group were significantly better(P<0.05).Conclusion NXTG with qi-enriching and blood-activating actions shows favorable effect in treating CHD patients with LVDD.

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