通心络胶囊对原发性高血压伴糖尿病患者血小板活化因子和炎症因子及内皮功能的影响

Effects of Tongxinluo Capsule on Platelet Activating and Inflammation Factors as well as Vascular Endothelial Function in Patients with Essential Hypertension Complicated with Diabetes Mellitus

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中文关键词: 通心络胶囊原发性高血压合并糖尿病炎症反应血小板活化血管内皮功能

英文关键词:Tongxinluo Capsule essential hypertension complicated with diabetes mellitus inflammation response platelet activation endothelial function

基金项目:江西省中医药管理局科技计划项目资助(No.2007A054)

作者	单位
陈章强	江西省人民医院心内科
洪浪	江西省人民医院心内科
王洪	江西省人民医院心内科
尹秋林	江西省人民医院心内科
赖珩莉	江西省人民医院心内科
陆林祥	江西省人民医院心内科

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中文摘要:

目的探讨通心络胶囊对原发性高血压(essential hypertension,EH)合并糖尿病(diabetes melli-tus,DM)患者血小板活化和血管炎症因子以及内皮功能的影响。方法100例EH合并DM患者分为超微粉通心络胶囊治疗组(简称通心络组50例)和常规治疗组(简称常规组50例),两组病例在入院后次日凌晨分别抽空腹肘静脉血,采用乳胶免疫增强比浊法测定血清高敏C反应蛋白(hs-CRP)水平;采用散射比浊法测定血浆纤维蛋白原(FIB-C)水平;采用流式细胞仪检测血小板活化指标CD62p及糖蛋白(GP)Ⅱb/Ⅲa受体复合物的表达水平;采用放射免疫测定法测定血浆内皮素-1(ET-1)的表达水平;采用酶法测定血浆一氧化氮(NO)的含量。同时选取健康体检者50名作为对照检测上述指标。并于治疗8周后复查上述指标与对照组进行比较。结果EH合并DM患者血清hs-CRP和血浆FIB-C、CD62p及GPⅡb/Ⅲa较对照组明显增高(均P<0.01);治疗8周后通心络组和常规组收缩压和舒张压均降低(P<0.05),hs-CRP、FIB-C、CD62p、GPⅡb/Ⅲa以及ET-1均有显著下降(均P<0.01),而且通心络组较常规组降低更明显(均P<0.05),NO升高更明显(P<0.05)。结论通心络胶囊可以抑制EH合并DM患者血小板激活和血管炎症反应,改善血管内皮功能,对防治EH合并DM引起血栓性疾病的并发症具有一定作用。

英文摘要:

Objective To explore the effects of Tongxinluo Capsule(TXLC) on platelet activating factor,vascular inflammation factor and vascular endothelial function in patients with essential hypertension(EH) complicated with diabetes mellitus(DM).Methods One hundred patients of EH with DM were equally assigned to the TXLC group(treated by TXLC) and the control group(treated with the conventional therapy).Their fasting blood drawn from the cubital vein on the next morning of hospitalization was taken for determining serum level of high sensitivity C-reactive protein(hs-CRP) by emulsion immunoenhancement turbidimetry;plasmal fibrinogen C(FIB-C) by diffusive turbidimetry;platelet activating indices,CD62p and glucose protein(GP) Ⅱb/Ⅲa receptor complex by flow cytometry;endothelin-1(ET-1) by radioimmunoassay and nitrogen oxide(NO) content by enzyme method.The outcomes were compared with those of 50 healthy persons.After patients were treated for 8 weeks,all the above-mentioned indices were reexamined and compared between groups.Results Blood levels of hs-CRP,FIB-C,CD62p,GPⅡb/Ⅲa and ET-1 in patients were significantly higher than those in healthy persons(all P<0.01).All the indices as well as the blood pressure(both systolic and diastolic) reduced in patients of both groups significantly(P<0.05 or P<0.01),but the reducing was more significant in the TXLC group than in the control group.Besides,level of NO significantly increased in the TXLC group(P<0.05).Conclusion TXLC can inhibit the platelet activation and vascular inflammation response,also improve the vascular endothelial function in patients with EH complicated with DM.It may play a certain role in preventing and treatment of the occurrence of thrombotic complications in them.

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