参芎补肾胶囊治疗血管性痴呆患者的疗效及对其生活质量的影响

作者	单位
郭明冬	中国中医科学院西苑医院老年科
周文泉	中国中医科学院西苑医院老年科
韦云	中国中医科学院西苑医院老年科
赵翠萍	中国中医科学院西苑医院老年科

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中文摘要:

目的观察参芎补肾胶囊的临床疗效,并探讨其作用机制。方法轻度血管性痴呆(vascular de-mentia,VaD)患者70例,按5∶2的比例随机分为治疗组50例与对照组20例。按双盲法给药,治疗组给予参芎补肾胶囊口服;对照组给予吡拉西坦片口服,疗程两个月。观察其对患者认知能力、日常生活能力、中医证候和生活质量的影响。结果据简易智能状态量表(The Mini-Mental State Examination,MMSE)测评认知能力疗效,总有效率治疗组74.46%,对照组68.42%,两组比较差异无统计学意义(P>0.05);日常生活能力(activity daily living,ADL)疗效,总有效率治疗组80.85%,对照组78.95%,两组比较差异无统计学意义(P>0.05);中医证候疗效,总有效率治疗组85.11%,对照组63.16%,治疗组优于对照组(P<0.05)。采用世界卫生组织发布的普适性生活质量量表——健康状况调查问卷(The Mos 36 item Short Form Health Survey,SF36)进行测评,显示参芎补肾治疗组对患者生活质量各维度积分及总积分均有较好的改善作用,治疗后优于治疗前(P<0.01,P<0.05);在生理功能(physical function,PF)、生理职能(role physical,RP)、活力(vital-ity,VT)诸维度及总积分方面,治疗组均较对照组改善明显(P<0.05)。结论参芎补肾胶囊对轻度VaD患者疗效肯定,具有较好的改善患者生活质量的作用;采用SF36对评定轻度VaD患者的生活质量具有一定的意义和可行性。

英文摘要:

Objective To observe clinical curative effect of Shenxiong Bushen Capsule for the treatment of mild vascular dementia (VaD),and probe the partial mechanism. Methods With a block random,double-blinded and controled clinical research method adopted,seventy patients with VaD were randomly assigned to two groups in a ratio of 5:2,including 50 cases in the trial group and 20 cases in the control group. The patients in the trial group were given the Shenxiong Bushen Capsule (5 tablets,thrice a day),while those in the control group were given Piracetam (5 tablets,twice a day). All patients of the two groups were treated for 2 months,and one third cases were follow-up surveyed for 1 month. The cognitive ability,the activities of daily living,Chinese medicine syndrome of VaD,and the quality of life were measured respectively before and after the treatment. Results According to the Mini-Mental State Examination,the clinical effects of patients showed that there was insignificant difference between the trial group (total effective rate was 74.46% and 80.85%,respectively) and the control group (total effective rate was 68.42% and 78.95%,respectively) on the cognitive ability and the activities of daily living (P>0.05),while the curative effect of the trial group (total effective rate was 85.11%) was superior to that of the control group (total effective rate was 63.16%) on Chinese medicine syndrome of VaD,and had significant difference between the two groups (P<0.05).The results measured by WHOQOL-SF36 indicated that the total scores and the scores of each field in both the trial group and the control group after treatment increased more than those of before treatment (P<0.01,P<0.05),except physical function (PF) field and role physical (RP) field of the control group (P>0.05). The scores of the trial group about total body,PF field,RP field and vitality (VT) field increased more than those of the control group (P<0.05); while no difference was shown between the trial group and control group in the scores of bodily pain field,role emotional field,general health field,social function field and mental health field (P>0.05). Conclusion Shenxiong Bushen Capsule has a definite curative effect on mild VaD,and it can improve the quality of life of patients. Adopting the SF36 Scale to evalute the quality of life of patients with VaD has significance and avaibility to some extent.

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