雷公藤多苷对白塞病患者血清白细胞介素-1β、白细胞介素-2、肿瘤坏死因子-α及干扰素-γ的影响

Effect of Tripterygium Glycosides on Serum Interleukin-1β,Interleukin-2,Tumor Necrosis Factor α,and Interferon-γ Levels in Patients with Behcet’s Disease

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中文关键词: 雷公藤多苷白塞病白细胞介素-1β 白细胞介素-2 肿瘤坏死因子-α 干扰素-γ

英文关键词:tripterygium glycosides Behcet’s disease interleukin-1β interleukin-2 tumor necrosis factor α interferon-γ

基金项目:2008济宁市科技局立项项目(济科字[2008]51号)

作者	单位
宋芹	山东省济宁医学院附属医院
芦济洲	山东省济宁医学院附属医院
李健	山东省济宁医学院附属医院
郭向华	山东省济宁医学院附属医院
党艳梅	山东省济宁医学院附属医院
李新建	山东省济宁医学院附属医院

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中文摘要:

目的观察雷公藤多苷对白塞病(Behcet′s disease,BD)患者血清白细胞介素(IL)-1β、IL-2,肿瘤坏死因子-α(TNF-α),干扰素-γ(IFN-γ)的影响,探讨雷公藤多苷治疗白塞病可能的机制。方法初治BD患者30例(BD组),给予雷公藤多苷片30mg/d,疗程3个月;另设对照组30例,均为健康体检者。采用放免法测定BD组治疗前后及对照组的血清IL-1β、IL-2、TNF-α及IFN-γ的水平。并结合血沉、C-反应蛋白及临床表现等情况进行分析。结果 (1)BD组患者治疗前血清IL-1β、TNF-α、IFN-γ水平明显高于对照组(P<0.05),IL-2水平亦较对照组升高,但差异无统计学意义(P>0.05)。(2)BD组雷公藤多苷治疗3个月后血清IL-1β[(5.71±1.04)μg/L]、TNF-α[(4.27±0.76)μg/L]及IFN-γ[(3.44±0.72)μg/L]水平较治疗前[(10.72±1.84)μg/L、(6.64±1.05)μg/L]及[(8.93±1.23)μg/L]均明显降低(P<0.05);IL-2水平与治疗前比较,差异无统计学意义(P>0.05)。(3)BD组30例,显效10例,有效16例,无效4例,有效率86.6%;治疗3个月后患者血沉、C-反应蛋白水平均较治疗前明显降低(P<0.05)。结论雷公藤多苷可能是通过降低血清IL-1β、TNF-α及IFN-γ水平而达到治疗作用。

英文摘要:

Objective To investigate the possible mechanism of action of tripterygium glycosides (TG) for treatment of Behcet’s disease (BD) through observing its effect on serum levels of interleukin-1β (IL-1β),inteleukin-2 (IL-2),tumor necrosis factor α (TNF-α) and interferon-γ (IFN-γ). Methods Thirty primarily treated BD patients (BD group) were treated with TG 30 mg/d orally for 3 months,and a control group consisting of 30 healthy persons was set up. Serum levels of IL-1β,IL-2,TNF-α and IFN-γ were detected by radio-immunosorbent assay (RIA) before and after treatment respectively. And the outcomes were analyzed in combining with the clinical status of patients as well as related indices as erythrocyte sedimentation (ESR) and C-reactive protein (CRP). Results Serum levels of IL-1β,TNF-α,IFN-γ in the BD group were evidently higher (P<0.05) than those in the control group,they all lowered significantly after 3-month TG treatment,from 10.72±1.84 μg/L,6.64±1.05 μg/L and 8.93±1.23 μg/L to 5.71±1.04 μg/L,4.27±0.76 μg/L and 3.44±0.72 μg/L,respectively (P<0.05),while level of IL-2 in the BD group was insignificantly different before treatment to that in the control (though showed an increasing trend) and was unchanged after treatment (P>0.05). TG treatment showed the effectiveness of markedly effective in 10,effective in 16 and ineffective in 4 BD patients,with the total effective rate of 86.6%. Besides,ESR and CRP levels were evidently decreased in BD patients after treatment (P<0.05). Conclusion TG may treat BD by way of regulating the levels of IL-1β,TNF-α and IFN-γ.

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