| 虞燕波,庄海舟,刘冲,段美丽,张淑文,李昂.芪参活血颗粒辅助治疗危重症患者急性肾损伤的疗效观察[J].中国中西医结合杂志,2010,30(8):819-822 |
| 芪参活血颗粒辅助治疗危重症患者急性肾损伤的疗效观察 |
| Effect of Qishen Huoxue Granule for Auxiliary Treatment of Critical Cases of Acute Kidney Injury |
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| DOI： |
| 中文关键词: 芪参活血颗粒 急性肾损伤 机械通气 血管活性药物 |
| 英文关键词:Qishen Huoxue Granules acute kidney injury mechanical ventilation vasoactive drugs |
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| 中文摘要: |
| 目的探讨应用中药芪参活血颗粒辅助治疗危重症患者急性肾损伤(AKI)的临床疗效。方法选择北京友谊医院重症医学科AKI患者52例,随机分为A组(25例)给予芪参活血颗粒(成分包括黄芪、丹参、赤芍、川芎、红花、当归等;10g/袋,每次10g,胃管注入,每天3次,疗程共14天)加血液滤过;B组(27例)给予血液滤过治疗。A、B两组中再根据是否应用机械通气分为A1亚组及B1亚组,是否应用血管活性药物分为A2亚组及B2亚组。分析比较A、B两组患者肾功能恢复时间、住重症监护病房(ICU)时间、28天病死率及血清中半胱氨酸蛋白酶抑制剂C(CystatinC)值的变化。同时比较A1亚组与B1亚组使用呼吸机时间的变化,以及A2亚组与B2亚组使用血管活性药物时间的变化。结果与B组比较,A组患者肾功能恢复时间早,血清CystatinC水平由第10天开始降低(P<0.05);A1亚组患者较B1亚组使用呼吸机时间短(P<0.05)。A2亚组患者较B2亚组使用血管活性药物时间短(P<0.05);住ICU时间及28天病死率两组比较,差异无统计学意义(P>0.05)。结论芪参活血颗粒可缩短肾功能恢复时间,缩短机械通气时间及血管活性药物使用时间,在治疗危重患者急性肾损伤方面显示了较好的治疗前景。 |
| 英文摘要: |
| Objective To explore the efficacy of Qishen Huoxue Granules(QHG) for auxiliary treatment of critical patients with acute kidney injury(AKI) .Methods Fifty-two AKI patients came from critical care medical department of Beijing Friendship Hospital were randomly assigned to two groups:Group A(25 patients) was treated with QHG(consisted of Radix Astragali,Radix Salviae miltiorrhizae,Radix Paeoniae rubra,Flos Carthami,and Radix Angelicae sinensis,etc.,10 g/bag,administered via gastric perfusion,3 times per day,10 g in each time) and continuous renal replacement therapy(CRRT);Group B(27 cases) was treated only by CRRT,all for 14 days.Besides,mechanical ventilation and vasoactive drugs were applied in case of necessary.The time of renal function recovery,days in ICU,28-day mortality,changes of serum Cystatin C concentration as well as the time of mechanical ventilation(T-V) and vasoactive drugs application(T-D) in patients,who received corresponding treatment were observed.Results The renal function recovery time in Group A was markedly earlier than that in Group B(P <0.05),with concentration of serum Cystatin C began to decrease from day 10.T-V and T-D in Group A were markedly shorter than those in Group B,respectively(P <0.05) .No significantly statistical difference between the two groups for days in ICU and 28-day mortality was found(P > 0.05) .Conclusion QHG shows favorable prospect in treating critical AKI patients,it can significantly accelerate the renal function recovery time,shorten the duration of mechanical ventilation and vasoactive drugs application. |
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