鸦胆子油注射液经支气管动脉灌注治疗晚期肺癌的临床研究

目的探讨支气管动脉灌注鸦胆子油注射液及化疗药物治疗晚期非小细胞肺癌的临床疗效。方法 103例晚期非小细胞肺癌随机分为2组。对照组50例,采用单纯支气管动脉灌注化疗,治疗组98例,采用鸦胆子油注射液结合化疗药行支气管动脉灌注,观察两组毒副反应发生率,肿瘤大小变化及生活质量评分。结果治疗组治疗肿瘤客观疗效(CR+PR)达63.3%,对照组46.0%,组间比较,差异有统计学意义(P<0.01);治疗组中位生存期363天,1年累积生存率为70.4%,对照组中位生存期为305天,1年累积生存率为44.0%,组间比较,差异亦有统计学意义(P<0.01)。治疗组生活质量改善率为83.7%,对照组为62.0%,组间比较,差异有统计学意义(P<0.01)。治疗组消化道反应、骨髓抑制、肝脏毒性、肾脏毒性、心脏毒性的毒副反应低于对照组(P<0.01)。结论鸦胆子油注射液结合化疗药行支气管动脉灌注治疗晚期非小细胞肺癌能提高客观疗效,并能提高生活质量、保护免疫功能及骨髓功能。

英文摘要:

Objective To explore the clinical effects of bronchial arterial infusion(BAI) with oleum fructus bruceae(OFB) Injection and chemotherapeutic agents(CTA) in treating advanced non-small cell lung cancer(NSCLC) .Methods One hundred and three patients with advanced NSCLC were randomized into 2 groups,the 98 patients in the treatment group treated by BAI with OFB + CTA and the 50 in the control group by BAI with CTA alone.The incidence of adverse reaction,change of tumor size and patients’ quality of life(QOL) in the two groups were observed and compared.Results The objective effective rate(CR + PR) was 63.3% in the treat-ment group and 46.0% in the control group(P <0.01);the median survival duration in them was 363 days and 305 days;the 1-year cumulative survival rate was 70.4% and 44.0%,and the QOF improving rate was 83.7% and 62.0% respectively,the difference between groups were all statistically significant(P <0.01) .In addition,the incidence of adverse reactions of digestive symptoms,bone marrow suppression and the hepato-,renal and cardiac toxicities were lower in the treatment group than those in the control group(P <0.01) .Conclusion BAI with OFB + CTA in treating NSCLC could enhance the objective therapeutic effect of simple chemotherapy,as well as raise the QOL and protect immune and medulla function in patients.

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