| 董千铜,章晓东,余震,夏建福,张波,胡礼,周锋,谈善军,王强.胃癌患者术后疲劳综合征的中西医结合治疗研究[J].中国中西医结合杂志,2010,30(10):1036-1040 |
| 胃癌患者术后疲劳综合征的中西医结合治疗研究 |
| Integrated Chinese and Western Medical Treatment on Postoperative Fatigue Syndrome in Patients with Gastric Cancer |
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| DOI： |
| 中文关键词: 术后疲劳综合征 营养支持 参麦注射液 胃癌 免疫功能 |
| 英文关键词:postoperative fatigue syndrome nutrition support Shenmai Injection gastric carcinoma immune function |
| 基金项目:浙江省医学重点扶植学科资助(07-F03);浙江省中医药管理局课题资助(No.2006C096) |
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| 中文摘要: |
| 目的观察参麦注射液联合肠内营养的治疗方案对胃癌患者术后疲劳综合征的影响。方法将58例胃癌患者分为肠外营养组(PN组,19例)、肠内营养组(EN组,19例)及综合治疗组(CT组,20例)。观察患者术后的一般恢复情况,用视觉模拟疲劳尺、心境量表、匹兹堡睡眠质量指数分别评估手术前后患者疲劳程度、心境变化、睡眠质量。同时术前1天和术后1、5、9天检测蛋白水平(总蛋白、白蛋白、前白蛋白)、T淋巴细胞亚群(CD3、CD4、CD8)、免疫球蛋白(IgG、IgM、IgA)。结果术后CT组一般恢复情况更快,心境状态好于EN组和PN组(P<0.05),睡眠质量指数评分低于PN组(P<0.05),术后疲劳程度较EN组和PN组减轻明显(P<0.05);术后9天CT组血清前白蛋白、CD3、CD4、CD4/CD8均比EN组和PN组相应指标增高(P<0.05),白蛋白、IgA水平高于PN组(P<0.05)。结论参麦注射液联合肠内营养的治疗方案具有一定睡眠情绪调节作用,并通过改善患者营养状态和免疫功能,减轻术后疲劳程度,加快康复。 |
| 英文摘要: |
| Objective To evaluate the effect of the combined use of Shenmai Injection(SMI)and enteral nutrition on postoperative fatigue syndrome(POFS)in patients with gastric cancer(GC).Methods Fifty-eight GC patients were randomized into the parenteral nutrition group(PNG,19 cases),enteral nutrition group(ENG,19 cases)and combined treatment group(CTG,20 cases).The post-operative recovery in patients was observed;patients’ conditions of fatigue,mood and sleep were evaluated respectively by visual analogue scale of fatigue,profile of mood states(POMS)and pittsburgh sleep quality index(PSQI).Meanwhile,nutritional variables,such as serum contents of total protein,albumin,pre-albumin,were measured at different time points:before operation(d0)and the 1st,5th,and 9th day(d1,d5 and d9)after operation.Immune variables such as subsets of lymphocytes(CD3,CD4,CD8),serum immunoglobulins(IgG,IgM,IgA)were also determined.Results Conditions of recovery,POMS and PSQI were better and the postoperative fatigue reduced more significantly in CTG than those in the other two groups(P<0.05).On d9,levels of pre-albumin,CD3,CD4,CD4/CD8 in CTG were significantly higher than those in the PNG and ENG(P<0.05),meantime,levels of albumin and IgA were higher in CTG than those in PNG(P<0.05).Conclusion Combined treatment of SMI and enteral nutrition can regulate mood and sleep to some extents,and reduce the postoperative fatigue through improving nutritional status and immune function,thus speeding up the recovery of patients. |
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