| 易正辉,朱丽萍,龙彬,姚培芬,赵根祥,沈阿珍,吴国君,吴海苏,张六平,汪作为,伍毅.帕罗西汀合并柴胡逍遥合剂治疗抑郁症的临床观察[J].中国中西医结合杂志,2010,30(12):1257-1260 |
| 帕罗西汀合并柴胡逍遥合剂治疗抑郁症的临床观察 |
| Clinical Observation on Treatment of Major Depressive Disorder by Paroxetine Combined with Chaihu Xiaoyao Mixture |
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| DOI： |
| 中文关键词: 柴胡逍遥合剂 帕罗西汀 抑郁症 疗效 安全性 |
| 英文关键词:Chaihu Xiaoyao Mixture paroxetine major depressive disorder efficacy safety |
| 基金项目:上海申康医院发展中心2007年中医验方项目(No.SHDC12007412) |
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| 中文摘要: |
| 目的评价柴胡逍遥合剂治疗抑郁症的临床疗效和安全性。方法将190例入组患者随机分为帕罗西汀合并柴胡逍遥合剂组(研究组)及帕罗西汀合并安慰剂组(对照组),分别于治疗前、治疗2、4、8周末评定汉密尔顿抑郁量表(HAMD-17)、临床疗效总评量表(CGI)及副反应量表(TESS)。结果 (1)研究组92例,完成随访89例,脱落3例,有效率84.8%,痊愈率69.6%;对照组98例,完成93例,脱落5例,有效率71.4%,痊愈率55.1%,两组比较差异有统计学意义(χ2=4.92,P<0.05;χ2=4.22,P<0.05);(2)与治疗前比较,两组在治疗后2、4及8周HAMD-17总分、各因子均分及CGI评分比较,差异均有统计学意义(P<0.01);两组间比较,HAMD-17总分及CGI评分在治疗8周差异有统计学意义(P<0.01);(3)两组不良反应比较,差异无统计学意义(P>0.05)。结论柴胡逍遥合剂合并帕罗西汀的疗效比单用帕罗西汀更显著,能提高临床有效率,安全性高。 |
| 英文摘要: |
| Objective To evaluate the efficacy and safety of Chaihu Xiaoyao Mixture (CXM) for the treatment of major depressive disorder (MDD).Methods One hundred and ninety patients with MDD were randomly assigned to two groups,the test group and the control group.They were treated by paroxetine combined with CXM or placebo for 8 weeks.The therapeutic efficacy was evaluated at the end of the 2nd,4th and 8th week by scoring according Hamilton Rating Scale for Depression (HAMD-17) and Clinical Global Impression (CGI) scale,and the adverse reaction was scaled by Treatment Emergent Symptoms Scale (TESS).Results Follow-up study was completed in 89/92 patients in the test group,and 93/98 patients in the control group,with 3 and 5 cases dropping,respectively.The effective rate in the two groups was 84.8% and 71.4%,and the cure rate was 69.6% and 55.1%,respectively,which were significantly higher in the test group than in the control group (χ2=4.92,P<0.05;χ2=4.22,P<0.05).As compared with the baseline,significant differences in HAMD-17 total score and scores of its various factors as well as the CGI score were shown in both groups after 2,4 and 8’s week treatment (P<0.01).Comparison between groups showed that significant differences presented in HAMD-17 total score and CGI score at the end of the 8th week (P<0.01),while comparison of adverse reactions between groups showed insignificantly statistical difference (P>0.05).Conclusion Combined treatment of CXM and paroxetine is more effective than that with paroxetine alone in treating MDD,and it could enhance the clinical efficacy with higher safety. |
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