轮泻停敷脐辅助治疗小儿轮状病毒肠炎的临床观察

作者	单位
吴瑛	兰州大学第一医院康复科
陈万强	兰州大学基础医学院中西医结合研究所
金玉	兰州大学第一医院小儿科

摘要点击次数: 1301

全文下载次数: 630

中文摘要:

目的观察轮泻停敷脐治疗小儿轮状病毒腹泻的临床疗效。方法 190例患儿依据就诊时间随机分为常规治疗组55例(甲组),以纠正脱水、酸中毒,口服补液盐(ORS)和抗病毒治疗为主;思密达组60例(乙组),在常规治疗组的基础上加用思密达,对<1岁者1.5g/次;1～2岁3g/次,用0.05L温水冲服;轮泻停敷脐治疗组75例(丙组),在常规治疗组的基础上用轮泻停药膏敷脐治疗,每天1剂(每剂含有生药6.0g),共7天。结果 3组患儿治疗过程中无脱落病例,治疗后,丙组的总有效率为92%,乙组为75%,甲组为69.1%,总有效率丙组与甲、乙两组比较,差异均有统计学意义(P<0.05),而甲、乙两组间比较,差异无统计学意义(P>0.05);同时,丙组有效降低了患儿血清TNF-α的水平,提升了血清IFN-γ的水平,与甲、乙两组比较,差异均有统计学意义(P<0.05)。3组治疗后均未见明显不良反应。结论轮泻停敷脐辅助治疗能有效缓解轮状病毒肠炎患儿腹泻程度,加快轮状病毒的转阴,降低了肠道黏膜的损伤程度。

英文摘要:

Objective To observe the clinical effect of umbilical application with Lunxieting Paste (LXT) for the treatment of infantile rotavirus enteritis (IRE).Methods One hundred and ninety infants with IRE were randomly assigned into three groups,55 in Group A,60 in Group B and 75 in Group C.All were treated with conventional therapy,mainly the dehydration and acidosis correcting,rehydration salt and antiviral therapy;but to patients in Groups B and C,anadditional medication of Smecta 1.5g,thrice a day.for infants below 1 year and 3g,thrice a day.for those between 1-2 years old,by orally taken with 0.05L of warm water and umbilical application with LXT (one dose per day,containing 6.0g of crude drug) was given respectively.Results The total effective rate was 69.1% in Group A,75% in Group B and 92% in Group C,respectively,showing significant difference (P<0.05) in comparing Group C with Groups A and B.Moreover,serum levels of TNF-α were decreased and IFN-γ increased in Group C after treatment,all showed statistical significance as compared with those in the other two groups (P<0.05).No significant adverse reactions were observed in all patients.Conclusion Umbilical application of LXT could effectively alleviate the diarrhea symptom in IRE patients,accelerate the negative inversion of rotavirus,and reduce the injury of intestinal membrane,showing a therapeutic efficacy more effective and quicker than that of conventional treatment with more convenience for use.

关闭